Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T cells
M. R. Shapiro, L. D. Peters, M. E. Brown, C. Cabello-Kindelan, A. L. Posgai, A. L. Bayer, T. M. Brusko
This study shows that IGF1 and IL-2 together expand regulatory T cells more effectively than either alone, through distinct signaling pathways and receptor expression changes.
bioRxiv · May 12, 2022Immunology