Author

A. L. Posgai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Pathology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

M. A. Atkinson· 3 shared C. H. Wasserfall· 2 shared M. A. Brusko· 2 shared M. R. Shapiro· 2 shared P. Thirawatananond· 2 shared T. M. Brusko· 2 shared A. K. Mojica-Avila· 1 shared A. L. Bayer· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersPathology

M. A. Atkinson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes

D. Drotar, A. K. Mojica-Avila, D. T. Bloss, C. M. Cohrs, C. T. Manson, A. L. Posgai, M. D. Williams, M. A. Brusko, E. A. Phelps, C. H. Wasserfall, S. Speier, M. A. Atkinson

The paper examines islet and acinar cell secretion in different pancreatic regions across diabetes stages, finding reduced insulin secretion and beta-cell volume in T1D with normal enzyme secretion.

bioRxiv · Feb 8, 2024 · PreprintPathology

Human immune phenotyping reveals accelerated aging in type 1 diabetes

M. R. Shapiro, X. Dong, D. Perry, J. M. McNichols, P. Thirawatananond, A. L. Posgai, L. Peters, K. Motwani, R. Musca, A. Muir, P. Concannon, L. Jacobsen, C. E. Mathews, C. H. Wasserfall, M. J. Haller, , T. M. Brusko

The paper uses flow cytometry to show accelerated immune aging and age-adjusted proinflammatory phenotypes in type 1 diabetes.

JCI Insight · Sep 8, 2023Peer-reviewedImmunology

Deletion of CD226 in Foxp3+ T cells Reduces Diabetes Incidence in Non-Obese Diabetic Mice by Improving Regulatory T Cell Stability and Function

P. Thirawatananond, M. Brown, L. Sachs, J. Arnoletti, W.-I. Yeh, A. L. Posgai, M. Shapiro, Y.-G. Chen, T. Brusko

This study shows that deleting CD226 in regulatory T cells reduces diabetes in NOD mice by enhancing Treg stability and function.

bioRxiv · Jun 2, 2022 · PreprintImmunology

Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T cells

M. R. Shapiro, L. D. Peters, M. E. Brown, C. Cabello-Kindelan, A. L. Posgai, A. L. Bayer, T. M. Brusko

This study shows that IGF1 and IL-2 together expand regulatory T cells more effectively than either alone, through distinct signaling pathways and receptor expression changes.

bioRxiv · May 12, 2022Immunology

ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas

I. Kusmartseva, W. Wu, F. Syed, V. van der Heide, M. Jorgensen, P. Joseph, X. Tang, E. Candelario-Jalil, C. Yang, H. Nick, J. Harbert, A. L. Posgai, R. Lloyd, S. Cechin, A. Pugliese, , M. A. Atkinson

This study examines ACE2 and SARS-CoV-2 expression in normal and COVID-19 pancreas tissues, finding prominent ACE2 expression in ductal epithelium and microvasculature, with limited endocrine cell expression and no strong evidence of SARS-CoV-2 infection of endocrine cells.

bioRxiv · Aug 31, 2020 · PreprintPathology