T. M. Brusko

Human immune phenotyping reveals accelerated aging in type 1 diabetes

The paper uses flow cytometry to show accelerated immune aging and age-adjusted proinflammatory phenotypes in type 1 diabetes.

Immune engineered extracellular vesicles to modulate T cell activation in the context of type 1 diabetes

This study generates engineered extracellular vesicles to modulate T cell activation in type 1 diabetes by presenting HLA-A2 and costimulatory molecules, showing they can activate or suppress CD8+ T cells depending on PD-L1 presence.

Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T cells

This study shows that IGF1 and IL-2 together expand regulatory T cells more effectively than either alone, through distinct signaling pathways and receptor expression changes.

Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

This paper demonstrates the use of induced pluripotent stem cells to create an isogenic system for studying genetic influences on cell-cell interactions in type 1 diabetes.

NADPH Oxidase 2 Derived Reactive Oxygen Species Promote CD8+ T cell Effector Function

This study shows that NOX2-derived reactive oxygen species are essential for CD8+ T cell effector function by promoting T-bet expression and mTOR complex 1 activation.