Author

M. E. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. L. Puetzer· 4 shared A. G. Gouldin· 1 shared A. L. Bayer· 1 shared A. L. Posgai· 1 shared A. S. Herbert· 1 shared A. Santiago-Gomez· 1 shared A. Sarmiento-Castro· 1 shared A. Sims· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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4 shared papersBioengineering

J. L. Puetzer

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Enthesis Maturation in Engineered Ligaments is Differentially Driven by Loads that Mimic Slow Growth Elongation and Rapid Cyclic Muscle Movement

M. E. Brown, J. L. Puetzer

This study investigates how slow stretch and cyclic loading differentially drive maturation of engineered entheses, improving interface mechanics and zonal composition.

Acta Biomaterialia · Dec 1, 2023Peer-reviewedBioengineering

Temporal Application of Lysyl Oxidase during Hierarchical Collagen Fiber Formation Differentially Effects Mechanics in Engineered Tissues

M. Bates, L. Troop, M. E. Brown, J. L. Puetzer

This study evaluates the effect of LOX treatment timing on collagen fiber formation and mechanics in engineered tissues, finding that LOXL2 supplementation at 4 weeks improves crosslinking and tissue strength.

bioRxiv · Oct 18, 2022Bioengineering

Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T cells

M. R. Shapiro, L. D. Peters, M. E. Brown, C. Cabello-Kindelan, A. L. Posgai, A. L. Bayer, T. M. Brusko

This study shows that IGF1 and IL-2 together expand regulatory T cells more effectively than either alone, through distinct signaling pathways and receptor expression changes.

bioRxiv · May 12, 2022Immunology

Driving Native-like Zonal Enthesis Formation in Engineered Ligaments Using Mechanical Boundary Conditions and β-Tricalcium Phosphate

M. E. Brown, J. L. Puetzer

This study uses mechanical boundary conditions and β-tricalcium phosphate to guide ligament fibroblasts to form zonal entheses with collagen organization and mineralization similar to immature bovine entheses.

bioRxiv · Jul 24, 2021Bioengineering

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

C. G. Rappazzo, L. V. Tse, C. I. Kaku, D. Wrapp, M. Sakharkar, D. Huang, L. M. Deveau, T. J. Yockachonis, A. S. Herbert, M. B. Battles, C. M. O'Brien, M. E. Brown, J. C. Geoghegan, J. Belk, L. Peng, , L. M. Walker

This study engineers an antibody, ADG-2, that broadly neutralizes SARS-CoV and SARS-CoV-2 in mice, offering protection against respiratory disease and viral replication.

bioRxiv · Nov 17, 2020 · PreprintImmunology

An Inducible Model for Unraveling the Effects of Advanced Glycation End-Products in Aging Connective Tissues

A. G. Gouldin, M. E. Brown, J. L. Puetzer

This study develops a method to induce AGE accumulation in collagen gels without affecting cell viability, enabling investigation of AGE effects on tissue mechanics and cell-matrix interactions.

bioRxiv · Sep 4, 2020Bioengineering

A dormant sub-population expressing interleukin-1 receptor characterises anti-estrogen resistant ALDH+ breast cancer stem cells

A. Sarmiento-Castro, E. Caamano-Gutierrez, A. Sims, M. I. James, A. Santiago-Gomez, R. Eyre, C. Clark, M. E. Brown, M. D. Brooks, D. F. Hayes, M. S. Wicha, S. J. Howell, R. Clarke, B. M. Simoes

The paper identifies a dormant ALDH+IL1R1+ sub-population in anti-estrogen resistant breast cancer stem cells and links IL1R1 expression to treatment failure.

bioRxiv · Oct 29, 2019Cancer Biology