LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency
M. N. O'Connor, D. M. Kallenberg, R. Jackstadt, A. H. Watson, M. Alatsatianos, J. Ohme, C. Camilli, C. Pilotti, A. Dritsoula, C. E. Bowers, L. Dowsett, J. George, X. Wang, A. Ager, O. J. Sansom, , J. Greenwood
This study shows that LRG1 promotes tumor vascular dysfunction and suppresses immunotherapy effectiveness, with its inhibition enhancing therapeutic outcomes in mouse cancer models.
bioRxiv · Oct 12, 2020Cancer Biology