A Chameleonic Macrocyclic Peptide with Drug Delivery Applications
C. D. Payne, B. Franke, M. F. Fisher, F. Hajiaghaalipour, C. E. McAleese, A. Song, C. Eliasson, J. Zhang, A. Jayasena, G. Vadlamani, R. J. Clark, R. F. Minchin, J. S. Mylne, K. J. Rosengren
The paper describes a chameleonic macrocyclic peptide, PDP-23, which can adopt different structures and is used to create a cell-penetrating inhibitor of the P-glycoprotein drug efflux pump.
bioRxiv · Dec 16, 2020 · PreprintBiochemistry