Author

R. J. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:plant (other)· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

C. D. Payne· 3 shared G. Vadlamani· 3 shared J. S. Mylne· 3 shared K. J. Rosengren· 3 shared M. F. Fisher· 3 shared F. Hajiaghaalipour· 2 shared J. Zhang· 2 shared A. A. Amarilla· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

C. D. Payne

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SARS-CoV-2 triggers complement activation through interactions with heparan sulfate

M. W. Lo, A. A. Amarilla, J. D. Lee, E. A. Albornoz, N. Modhiran, R. J. Clark, V. Ferro, M. Chhabra, A. A. Khromykh, D. Watterson, T. M. Woodruff

This study shows SARS-CoV-2 activates the complement system via heparan sulfate interactions, leading to C5a production and delayed granulocyte/monocyte activation.

bioRxiv · Jan 11, 2022Immunology

Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides

C. D. Payne, G. Vadlamani, F. Hajiaghaalipour, T. Muhammad, M. F. Fisher, H. S. Andersson, U. Göransson, R. J. Clark, C. S. Bond, J. S. Mylne, K. J. Rosengren

The paper uses solution NMR and racemic crystallography to characterize the structure of PDP-23 and related peptides, revealing their unique folding and potential as drug scaffolds.

bioRxiv · Jul 28, 2021Biochemistry

A Chameleonic Macrocyclic Peptide with Drug Delivery Applications

C. D. Payne, B. Franke, M. F. Fisher, F. Hajiaghaalipour, C. E. McAleese, A. Song, C. Eliasson, J. Zhang, A. Jayasena, G. Vadlamani, R. J. Clark, R. F. Minchin, J. S. Mylne, K. J. Rosengren

The paper describes a chameleonic macrocyclic peptide, PDP-23, which can adopt different structures and is used to create a cell-penetrating inhibitor of the P-glycoprotein drug efflux pump.

bioRxiv · Dec 16, 2020 · PreprintBiochemistry

Defining the familial fold of the vicilin-buried peptide family

C. D. Payne, G. Vadlamani, M. F. Fisher, J. Zhang, R. J. Clark, J. S. Mylne, K. J. Rosengren

The paper characterizes the structural features of Vicilin Buried Peptides (VBPs) using solution NMR spectroscopy, revealing a helix-loop-helix hairpin fold stabilized by disulfide bonds and inter-helix interactions.

bioRxiv · May 26, 2020Biochemistry