Author

K. J. Rosengren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:plant (other)· 4 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. S. Mylne· 5 shared M. F. Fisher· 5 shared C. D. Payne· 4 shared G. Vadlamani· 3 shared R. J. Clark· 3 shared F. Hajiaghaalipour· 2 shared J. Zhang· 2 shared A. Jayasena· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBiochemistry

J. S. Mylne

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5 papers

Recent·Most cited

Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides

C. D. Payne, G. Vadlamani, F. Hajiaghaalipour, T. Muhammad, M. F. Fisher, H. S. Andersson, U. Göransson, R. J. Clark, C. S. Bond, J. S. Mylne, K. J. Rosengren

The paper uses solution NMR and racemic crystallography to characterize the structure of PDP-23 and related peptides, revealing their unique folding and potential as drug scaffolds.

bioRxiv · Jul 28, 2021Biochemistry

Structural Characterization of the PawL-Derived Peptide Family, an Ancient Subfamily of Orbitides

C. D. Payne, M. F. Fisher, J. S. Mylne, K. J. Rosengren

The paper characterizes the structural features of nine PawL-Derived Peptides (PLPs), revealing beta-turns and sequence diversity but no antibacterial or antifungal activity.

bioRxiv · Jul 18, 2021Biochemistry

A Chameleonic Macrocyclic Peptide with Drug Delivery Applications

C. D. Payne, B. Franke, M. F. Fisher, F. Hajiaghaalipour, C. E. McAleese, A. Song, C. Eliasson, J. Zhang, A. Jayasena, G. Vadlamani, R. J. Clark, R. F. Minchin, J. S. Mylne, K. J. Rosengren

The paper describes a chameleonic macrocyclic peptide, PDP-23, which can adopt different structures and is used to create a cell-penetrating inhibitor of the P-glycoprotein drug efflux pump.

bioRxiv · Dec 16, 2020 · PreprintBiochemistry

The genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides

M. F. Fisher, C. Payne, T. Chetty, D. Crayn, O. Berkowitz, J. Whelan, K. J. Rosengren, J. S. Mylne

The paper rediscovered evolidine, a plant cyclic peptide, and identified its biosynthetic origin through de novo transcriptomics, revealing a diverse family of related peptides in Rutaceae.

bioRxiv · Jun 10, 2020Biochemistry

Defining the familial fold of the vicilin-buried peptide family

C. D. Payne, G. Vadlamani, M. F. Fisher, J. Zhang, R. J. Clark, J. S. Mylne, K. J. Rosengren

The paper characterizes the structural features of Vicilin Buried Peptides (VBPs) using solution NMR spectroscopy, revealing a helix-loop-helix hairpin fold stabilized by disulfide bonds and inter-helix interactions.

bioRxiv · May 26, 2020Biochemistry