Author

H. Zong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

L. Wang· 6 shared B. Zhang· 4 shared H. Jiang· 4 shared H. Ma· 4 shared H. Tang· 4 shared H. Yin· 4 shared J. Liu· 4 shared J. Zhu· 4 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersCell Biology

L. Wang

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations

C. Abecunas, A. D. Kidd, Y. Jiang, H. Zong, M. Fallahi-Sichani

The paper identifies metabolic state vulnerabilities in cancer cell lines and discovers synthetically lethal associations between metabolism, mutations, and therapeutic targets.

bioRxiv · Nov 28, 2023Cancer Biology

A genetic mosaic mouse model illuminates the pre-malignant progression of basal-like breast cancer

J. Zeng, S. Singh, Y. Jiang, E. Casarez, K. A. Atkins, K. A. Janes, H. Zong

This paper develops a mouse model to study the pre-malignant progression of basal-like breast cancer, revealing stepwise lesion development and spatially resolved mutant cell analysis.

bioRxiv · Apr 25, 2023Cancer Biology

Long-term passaging of replication competent pseudo-typed SARS-CoV-2 reveals the antiviral breadth of monoclonal and bispecific antibody cocktails

J. Zhu, H. Ma, H. Zong, J. Liu, Y. Yue, Y. Ke, Y. Liao, H. Tang, L. Wang, S. Wang, Y. Yuan, M. Wu, Y. Bian, B. Zhang, H. Yin, , Y. Xie

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

bioRxiv · Oct 5, 2022 · PreprintCell Biology

Neuronal glucose metabolism sets cholinergic tone and controls thermo-regulated signaling at the neuromuscular junction

Y. Tang, H. Zong, H. Kwon, Y. Qiu, J. B. Pessin, L. Wu, K. A. Buddo, I. Boykov, C. Schmidt, C.-T. Lin, P. D. Neufer, G. J. Schwartz, I. J. Kurland, J. E. Pessin

This study shows that increasing glycolysis in cholinergic neurons boosts acetylcholine levels, reduces blood pressure and heart rate, and improves cold resistance.

eLife · Mar 7, 2022Peer-reviewedCell Biology

Efficient Neutralization of SARS-CoV-2 Omicron and Other VOCs by a Broad Spectrum Antibody 8G3

H. Ma, C.-T. K. Tseng, H. Zong, Y. Liao, Y. Ke, H. Tang, L. Wang, Z. Wang, Y. He, Y. Chang, S. Wang, A. Drelich, J. Hsu, V. Tat, Y. Yuan, , J. Zhu

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

bioRxiv · Feb 25, 2022 · PreprintCell Biology

Quantitative clonal analysis reveals vast heterogeneity among fallopian tube cells for ovarian cancer-initiation and progression

J. Zeng, A. A. Yela, E. Casarez, Y. Jiang, L. Wang, B. E. Kelly, E. Ke, T. M. Jenkins, K. A. Atkins, K. A. Janes, J. K. Slack-Davis, H. Zong

This study uses quantitative clonal tracing in mice to show that only a rare subset of distal fallopian tube cells can initiate and progress serous ovarian cancer.

bioRxiv · Jan 23, 2022 · PreprintCancer Biology

Comprehensive Evaluation of ACE2-Fc Combination with Neutralization Antibody on Broad Protection against SARS-CoV-2 and Its Variants

H. Tang, Y. Ke, H. Ma, L. Han, L. Wang, H. Zong, Y. Yuan, Z. Wang, Y. He, Y. Chang, S. Wang, J. Liu, Y. Yue, W. Xu, X. Zhang, , J. Zhu

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

bioRxiv · Jan 17, 2022 · PreprintCell Biology

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

H. Ma, Y. Guo, H. Tang, C.-T. Tseng, L. Wang, H. Zong, Z. Wang, Y. He, Y. Chang, S. Wang, H. Huang, Y. Ke, Y. Yuan, M. Wu, Y. Zhang, , J. Zhu

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

bioRxiv · Sep 24, 2021Cell Biology

Premalignant Nf1,Trp53-null Oligodendrocyte Precursor Cells BecomeStalled in a Heterogeneous State of Replication Stress BeforeGliomagenesis

M. Sutcliffe, R. Galvao, L. Wang, J. Kim, L. Rosenfeld, S. Singh, H. Zong, K. Janes

This study identifies replication stress in premalignant OPCs before glioma formation using stochastic profiling in a mouse model.

Cancer Research · Feb 2, 2021Peer-reviewedCancer Biology

Spatial Regulation of MCAK Promotes Cell Polarization and Focal Adhesion Turnover to Drive Robust Cell Migration

H. Zong, M. Hazelbaker, C. Moe, S. C. Ems-McClung, K. Hu, C. E. Walczak

This study shows that MCAK's spatial distribution regulates cell migration by affecting MT dynamics, cell polarization, and focal adhesion turnover in RPE-1 cells.

bioRxiv · Apr 30, 2020Cell Biology