Tetracycline-dependent inhibition of mitoribosome protein elongation in mitochondrial disease mutant cells suppresses IRE1α to promote cell survival
C. T. Ronayne, C. F. Bennett, E. A. Perry, N. Kantorovich, P. Puigserver
The paper shows tetracyclines suppress IRE1α in mitochondrial disease cells by inhibiting mitoribosome elongation, promoting survival during glucose starvation.
bioRxiv · Mar 9, 2023 · PreprintCell Biology