Author

D. L. Spector

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

S. Bhatia· 3 shared S. Russo· 3 shared A. T. Yu· 2 shared F. Rigo· 2 shared K. Kostroff· 2 shared T. Ha· 2 shared A. Alpsoy· 1 shared A. Rishi· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

S. Bhatia

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

MARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer

O. Klingbeil, D. Skopelitis, C. Tonelli, A. Alpsoy, F. Minicozzi, D. Aggarwal, S. Russo, T. Ha, O. E. Demerdash, D. L. Spector, D. A. Tuveson, P. Cifani, C. R. Vakoc

This study identifies MARK2/3 as essential kinases for YAP/TAZ function in cancer and shows their inhibition can restore Hippo pathway tumor suppression.

bioRxiv · Feb 26, 2024Cancer Biology

Allele pairing at Sun1-enriched domains at the nuclear periphery via T1A3 tandem DNA repeats

G. I. Balasooriya, D. L. Spector

The paper shows that alleles of monoallelic genes are paired at Sun1-enriched nuclear periphery domains, enriched with T1A3 repeats and bound by Hnrnpd.

bioRxiv · Apr 7, 2023 · PreprintCell Biology

Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics

S. Bhatia, M. Kramer, S. Russo, P. Naik, G. Arun, K. Brophy, P. A. Andrews, C. Fan, C. M. Perou, J. Preall, T. Ha, D. Plenker, D. Tuveson, A. Rishi, J. E. Wilkinson, , D. L. Spector

This study develops and characterizes patient-derived TNBC organoids that recapitulate tumor properties and identify key signaling pathways involved in cancer progression.

bioRxiv · Aug 9, 2021Cancer Biology

PHAROH lncRNA regulates c-Myc translation in hepatocellular carcinoma via sequestering TIAR

A. T. Yu, C. Berasain, S. Bhatia, K. Rivera, B. Liu, F. Rigo, D. J. Pappin, D. L. Spector

The paper identifies PHAROH, an lncRNA overexpressed in hepatocellular carcinoma, which regulates c-Myc translation by sequestering TIAR, impacting cell proliferation and migration.

bioRxiv · Mar 23, 2021Cancer Biology

MaTAR25 LncRNA Regulates the Tensin1 Gene to Impact Breast Cancer Progression

K.-C. Chang, S. D. Diermeier, A. T. Yu, L. D. Brine, S. Russo, S. Bhatia, H. Alsudani, K. Kostroff, T. Bhuiya, E. Brogi, C. F. Bennett, F. Rigo, D. L. Spector

This study identifies MaTAR25 and its human ortholog LINC01271 as lncRNAs that regulate Tns1 expression, impacting breast cancer progression through actin cytoskeleton and focal adhesion changes.

bioRxiv · Feb 3, 2020Cancer Biology

A lncRNA/Lin28/Let7 Axis Coupled To DNA Methylation Fine Tunes The Dynamics Of A Cell State Transition

M. A. Li, P. P. Amaral, P. Cheung, J. H. Bergmann, M. Kinoshita, T. Kalkan, M. Ralser, S. Robson, F. von Meyenn, M. Paramor, F. Yang, C. Chen, J. Nichols, D. L. Spector, T. Kouzarides, , A. Smith

The paper identifies a lncRNA/miRNA/DNA methylation axis that regulates the timing of stem cell state transition from naive pluripotency.

bioRxiv · Apr 26, 2017Cell Biology