S. Russo

Electrical stimulation elicits space- and parameter-dependent spiking responses in human cortical organoids

This study shows how electrical stimulation affects spiking responses in human cortical organoids, finding parameter-dependent excitatory and inhibitory responses with local circuit contributions.

MARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer

This study identifies MARK2/3 as essential kinases for YAP/TAZ function in cancer and shows their inhibition can restore Hippo pathway tumor suppression.

Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice

This study shows that CCL5-CCR5 signaling in the prefrontal cortex of female mice contributes to stress susceptibility by altering microglia function and BBB integrity.

Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice

This study investigates the distinct roles of caspase-8 and MLKL in high-fat diet-induced obesity and NAFLD in mice, showing that MLKL contributes to disease independently of inflammation.

Formulating a TMEM176B blocker in nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity.

This paper develops a nanoparticle formulation of BayK8644 that enhances its anti-tumoral efficacy by separating its dual effects on innate and adaptive immunity.

The ZNF687 mutation of Paget's disease associated with giant cell tumour causes severe bone remodelling alteration as a result of a deregulated osteoclast transcriptional program

This study identifies a ZNF687 mutation causing Paget's disease by disrupting osteoclast function and bone remodeling in mice.

Profilin 1 deficiency drives mitotic defects and impairs genome stability

This study shows that Profilin 1 deficiency causes mitotic defects and genome instability in cancer cells.

Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics

This study develops and characterizes patient-derived TNBC organoids that recapitulate tumor properties and identify key signaling pathways involved in cancer progression.

A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines

The paper describes a pipeline for generating personalized oncolytic cancer vaccines using immunopeptidomic data and validates it in a murine colon tumor model.

The long non-coding RNA MaTAR20 promotes mammary tumor growth by regulating angiogenesis pathways

This study identifies MaTAR20 as a lncRNA that promotes mammary tumor growth by regulating angiogenesis pathways, specifically through its interaction with Tnfsf15.

MaTAR25 LncRNA Regulates the Tensin1 Gene to Impact Breast Cancer Progression

This study identifies MaTAR25 and its human ortholog LINC01271 as lncRNAs that regulate Tns1 expression, impacting breast cancer progression through actin cytoskeleton and focal adhesion changes.