Author

H. A. Bunzel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. J. Mulholland· 4 shared M. W. van der Kamp· 3 shared R. Anderson· 2 shared A. Davidson· 1 shared A. Finn· 1 shared A. Harrison· 1 shared B. Vidana Matteo· 1 shared C. Fletcher· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersBiochemistry

A. J. Mulholland

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4 papers

Recent·Most cited

Electric fields determine carbapenemase activity in class A β-lactamases

H. Jabeen, M. Beer, J. Spencer, M. W. van der Kamp, H. A. Bunzel, A. J. Mulholland

The paper investigates how electric fields in class A β-lactamases influence carbapenemase activity using molecular dynamics simulations and identifies key positions that correlate with enzyme efficiency.

bioRxiv · Nov 4, 2023Biochemistry

Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution

C. Frohlich, H. A. Bunzel, K. Buda, A. J. Mulholland, M. W. van der Kamp, P. J. Johnsen, H.-K. S. Leiros, N. Tokuriki

This study shows that epistasis in enzyme evolution arises from shifting the rate-limiting step in the catalytic cycle, leading to substantial activity enhancements through synergistic mutations.

bioRxiv · Jun 29, 2023Evolutionary Biology

Antibodies generated in vitro and in vivo elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

D. Buzas, H. A. Bunzel, O. Staufer, E. Milodowski, G. Edmonds, J. Bufton, B. Vidana Matteo, S. Yadav, K. Gupta, C. Fletcher, M. Kavanagh Williamson, A. Harrison, U. Borucu, J. Capin, O. Francis, , I. Berger

This study develops a thermostable ADDomer-based nanoparticle vaccine that neutralizes SARS-CoV-2 and cross-reacts with VOCs, demonstrating its potential for nasal administration.

bioRxiv · Mar 17, 2023Biochemistry

Evolution of dynamical networks enhances catalysis in a designer enzyme

H. A. Bunzel, R. Anderson, D. Hilvert, V. L. Arcus, M. W. van der Kamp, A. J. Mulholland

This study shows that directed evolution of a designer enzyme introduces dynamical changes that increase activation heat capacity and nonlinearity in temperature dependence through correlated dynamical networks.

bioRxiv · Aug 21, 2020Biochemistry