Simultaneous, cell-intrinsic downregulation of PD-1 and TIGIT enhances the effector function of CD19-targeting CAR T cells and promotes an early-memory phenotype
Y. Lee, H. J. Lee, H. C. Kim, Y. Lee, S. K. Nam, C. Hupperetz, J. S. Ma, X. Wang, O. Singer, W. S. Kim, S. J. Kim, Y. Koh, I. Jung, C. H. Kim
This paper shows that simultaneously reducing PD-1 and TIGIT in CAR T cells improves their antitumor activity and memory phenotype in mouse models.
bioRxiv · Nov 7, 2020 · PreprintImmunology