H. J. Lee

Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for AML cell self-renewal.

This study shows that hypomethylating agents induce epigenetic and transcriptional heterogeneity in AML cells, with some cells retaining methylation and showing increased self-renewal, and identifies statins as a potential co-treatment to enhance HMA efficacy.

Hypoxia alters the effects of hypomethylating agents in acute myeloid leukaemia cells.

This study shows hypoxia reduces the effectiveness of hypomethylating agents in AML cells by altering DNA methylation and antigen presentation pathways.

CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin

The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.

14K Prolactin Derived 14-Mer Antiangiogenic Peptide Targets Bradykinin-/Nitric Oxide-cGMP-Dependent Angiogenesis

This study identifies a novel 14-mer antiangiogenic peptide derived from prolactin that inhibits bradykinin- and eNOS-dependent angiogenesis, showing synergistic effects with Avastin in a colon cancer model.

Automated cell annotation in multi-cell images using an improved CRF_ID algorithm

This paper improves the CRF_ID algorithm for multi-cell imaging in C. elegans, enhancing its accuracy and generalizability beyond whole-brain imaging.

CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites.

This study examines CD4+ T cell recall dynamics during Plasmodium re-infection in mice, revealing a spectrum of responses including refractory GC Tfh cells, rapid Th1-memory responses, and a partial facsimile of primary Th1 responses.

Spatial transcriptomics maps molecular and cellular requirements for CD4+ T cell-dependent immunity to malaria.

This paper uses spatial transcriptomics to map CD4+ T cell and B cell interactions in the spleen during malaria infection, revealing their localization and molecular requirements for immunity.

Chloroplast protein import determines plant proteostasis and retrograde signaling

This study shows that chloroplast protein import and proteases regulate polyQ proteostasis in plants, with implications for human disease therapy.

LIPA-driven hydrolysis of cholesteryl arachidonate promotes cancer metastasis via NF-κB

This study identifies LIPA as a key regulator of CE hydrolysis in cancer cells, showing that its inhibition suppresses metastasis via suppression of NF-κB signaling.

No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination

This study investigates whether COVID-19 mRNA vaccination affects pregnancy outcomes or induces anti-syncytin-1 antibodies, finding no evidence of fetal defects or increased antibody levels.

Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies

The paper investigates how motor protein properties affect microtubule assembly dynamics and structure, showing that motor speed and processivity determine aster size and contraction rates.

Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites

The paper shows that systemic host inflammation slows malaria parasite maturation and alters their transcriptomic profile in vivo.

Hormonal contraceptives alter amphetamine place preference and responsivity in the intact female rat.

This study examines how hormonal contraceptives and ovarian hormone levels affect amphetamine place preference and responsivity in female rats, finding that proestrus rats show higher preference and dopaminergic activity.

Expression patterns of Arc mRNA after renewal of appetitive behavior in female rats.

This study examines how estrous cycle stages affect renewal of appetitive behavior in female rats, showing differential Arc mRNA expression in specific brain regions.

Atmospheric plasma jet device for versatile electron microscope grid treatment

This paper introduces a non-thermal atmospheric plasma jet system for treating electron microscope grids, enabling hydrophilic surface modification without vacuum requirements.

The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress

This study identifies enhanced proteostasis mechanisms in Arabidopsis root stem cells that protect against proteotoxic stress by maintaining protein homeostasis through high levels of TRiC/CCT chaperones.

Pre-conditioning Modifies the Tumor Microenvironment to Enhance Solid Tumor CAR T Cell Efficacy and Endogenous Immunity

This study shows that cyclophosphamide pre-conditioning improves CAR T cell efficacy against solid tumors by modifying the immunosuppressive tumor microenvironment without harming normal tissues.

Simultaneous, cell-intrinsic downregulation of PD-1 and TIGIT enhances the effector function of CD19-targeting CAR T cells and promotes an early-memory phenotype

This paper shows that simultaneously reducing PD-1 and TIGIT in CAR T cells improves their antitumor activity and memory phenotype in mouse models.

Not out of the box: phylogeny of the broadly sampled Buxaceae

The paper estimates the phylogeny of Buxaceae using molecular data from four chloroplast markers and nuclear ribosomal ITS, describing new subfamilies, genera, and species.

How to map a plantain: phylogeny of the diverse Plantagineae (Lamiales)

This study presents the broadest phylogeny of the Plantagineae tribe, revealing evolutionary and biogeographical insights and describing two new species.

Size-dependent protein segregation creates a spatial switch for Notch signaling and function

The paper shows that spatial constraints at cadherin-based adherens junctions regulate Notch cleavage by gamma-secretase, affecting signaling and cell differentiation.

Th2-like T-follicular helper cells promote functional antibody production during Plasmodium falciparum infection

The paper identifies Th2-like T-follicular helper cells as key drivers of functional antibody production during Plasmodium falciparum infection, suggesting they are targets for improved malaria vaccines.

A Thermodynamic Interpretation of the Stimulated Raman Spectroscopic Signature to Action Potential in Single Neurons

The paper uses hyperspectral stimulated Raman spectroscopy to show that neuronal membrane thermodynamic state changes during action potentials, supporting the acoustic hypothesis.

Targeted Eicosanoid Profiling Reveals MicroRNA-155 Shifts PGE2/PGD2 Balance Towards Oncogenic State

This study shows miR-155 shifts PGE2/PGD2 balance towards an oncogenic state by regulating enzymes involved in prostaglandin synthesis.

Single-cell transcriptomics of allo-reactive CD4+ T cells over time reveals divergent fates during gut GVHD

This study uses single-cell RNA sequencing to track the differentiation of allo-reactive CD4+ T cells during gut GVHD, revealing divergent fates into quiescent and effector states.

Transcriptome Dynamics Reveals Progressive Transition from Effector to Memory in CD4+ T cells.

This study uses single-cell RNA-seq and ATAC-seq to show a progressive transition from effector to memory CD4+ T cells during Plasmodium infection, with linear pathways and memory-associated gene expression.

Controlling Organization and Forces in Active Matter Through Optically-Defined Boundaries

This paper demonstrates the use of optically-defined boundaries to control active matter systems of microtubules and motor proteins, enabling the creation of contractile networks and fluid flows.

Connecting the dots between mechanosensitive channel abundance, osmotic shock, and survival at single-cell resolution

The paper quantifies the number of MscL channels required for E. coli survival after osmotic shock using single-cell fluorescence microscopy and finds that 500-700 channels per cell are needed for 80% survival.

A Kaposi’s Sarcoma-Associated Herpesvirus Infection Mechanism is Independent of Integrins α3β1, αVβ3, and αVβ5

This study identifies an integrin-independent KSHV infection mechanism requiring HS and EphA2 but not Vβ1-family integrins or EphA2 intracellular domain.

Parkin knockout inhibits neuronal development via regulation of proteasomal degradation of p21

This study shows parkin knockout inhibits neural stem cell differentiation through JNK-dependent proteasomal degradation of p21.