S. J. Kim

ER-to-lysosome Ca2+ refilling followed by K+ efflux-coupled store-operated Ca2+ entry in inflammasome activation and metabolic inflammation

This study identifies a novel mechanism involving lysosomal Ca2+ release and K+ efflux through KCa3.1 channels in inflammasome activation and metabolic inflammation.

Rapid and label-free exosome analysis by surface-enhanced Raman spectroscopy using silver nanoparticle substrate based on selective laser ablation and melting of silver nanowire

This paper presents a rapid, label-free method for detecting breast cancer-derived exosomes using SERS with a silver nanoparticle substrate fabricated via laser ablation and melting.

EZH2 inhibition stimulates viral mimicry in resting splenic B cells

EZH2 inhibition causes repeat misexpression and B cell death by mimicking viral infection in splenic B cells.

A deep CNN framework for neural drive estimation from HD-EMG across contraction intensities and joint angles

This paper introduces a deep CNN framework to estimate neural drive from HD-EMG across varying contraction intensities and joint angles, achieving high accuracy without retraining for new conditions.

The Arabidopsis ORA59 coordinates jasmonic acid- and ethylene-responsive gene expression to regulate plant immunity

This study identifies ERELEE4 as an ORA59-binding cis-element and shows ORA59 regulates JA/ET-responsive genes through direct promoter binding, with differential preference for GCC box and ERELEE4 based on hormone activation.

Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

The paper depletes adult microglia using CSF1R inhibition and shows that subventricular zone/white matter myeloid cells dynamically repopulate the brain, exhibiting distinct phenotypes from endogenous microglia.

Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-Mediated Rejection

The paper identifies increased levels of specific non-HLA autoantibodies in kidney transplant patients with antibody-mediated rejection.

Simultaneous, cell-intrinsic downregulation of PD-1 and TIGIT enhances the effector function of CD19-targeting CAR T cells and promotes an early-memory phenotype

This paper shows that simultaneously reducing PD-1 and TIGIT in CAR T cells improves their antitumor activity and memory phenotype in mouse models.

Phosphorylation of the RB C-terminus regulates condensin II release from chromatin

This study shows that phosphorylation of RB at S838/T841 regulates its interaction with condensin II on chromatin, affecting genome stability.

Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel

This study shows that calhm1 ion channel activation is thermosensitive, with increased amplitude and faster activation at higher temperatures, independent of extracellular calcium concentration.

Robust and sensitive detection of SARS-CoV-2 using PCR based methods

This study compares qPCR and ddPCR for SARS-CoV-2 detection, finding ddPCR more sensitive and accurate in quantifying viral RNA from various sources.

Gut bacteria convert cortisol into a distinct hostsignalling molecule

The paper shows gut bacteria convert cortisol into 20-dihydrocortisol, a distinct host signalling molecule that reprograms colonic transcription and activates inflammatory pathways via NR4A3.

Development of Reverse Transcription Loop-mediated Isothermal Amplification (RT-LAMP) Assays Targeting SARS-CoV-2

This study develops and evaluates RT-LAMP assays for SARS-CoV-2 detection, achieving sensitivity of 100 copies and no cross-reactivity with other human coronaviruses, with an adapted colorimetric detection method for higher throughput.

Comparative analysis of primer-probe sets for the laboratory confirmation of SARS-CoV-2

This study compares the sensitivity of primer-probe sets for detecting SARS-CoV-2 RNA in N and Orf1 genes, identifying the most sensitive sets for each.

Implantable electrical stimulation bioreactor with liquid crystal polymer based electrodes for enhanced bone regeneration at mandibular large defects in rabbit

This study demonstrates that an implantable electrical stimulation bioreactor with liquid crystal polymer electrodes enhances bone regeneration in rabbit mandibular defects compared to a sham control and rhBMP-2 treatment.

Structural basis of recognition and destabilization of histone H2B ubiquitinated nucleosome by DOT1L histone H3 Lys79 methyltransferase

The paper presents cryo-EM structures of DOT1L with nucleosomes and shows H2B ubiquitination enhances DOT1L's non-catalytic nucleosome destabilization function.

A proteolytic complex targets multiple cell wall hydrolases in Pseudomonas aeruginosa

This paper identifies CtpA and its partner LbcA as a proteolytic complex in Pseudomonas aeruginosa that degrades peptidoglycan cross-link hydrolases, regulating virulence and cell wall remodeling.

Integrative structure investigation on the architecture of human Importin4_histone H3/H4_Asf1a complex and its histone H3 tail binding

This study investigates the structure of the Importin4_histone H3/H4_Asf1a complex and identifies key interactions between Importin4 and the histone H3 tail.