Y. Koh

Single-cell RNA sequencing reveals characteristics of myeloid cells in pulmonary post-acute sequelae of SARS-CoV-2

This study uses single-cell RNA sequencing to analyze myeloid cells in PBMCs from PPASC patients and controls, identifying increased myeloid lineage cells and altered gene expression linked to fibrosis and immune suppression.

AMLs harboring DNMT3A-destabilizing variants show increased intratumor DNA methylation heterogeneity at bivalent chromatin domains

This study shows that DNMT3A-destabilizing mutations in AML increase DNA methylation heterogeneity at bivalent chromatin domains, affecting leukemic stem cell-niche interactions and drug response.

Mitigating the Bfl-1-mediated antiapoptotic pathway in diffuse large B cell lymphoma by inhibiting HDACs

The paper withdraws due to the need for further experiments to validate conclusions about Bfl-1 and HDAC inhibition in diffuse large B cell lymphoma.

Clinical and immunological signatures of severe COVID-19 in previously healthy patients with clonal hematopoiesis

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

Transcriptional analysis of immune modulatory genes in melanoma treated with PD-1 blockade

The paper identifies key immune genes and develops a transcriptional deviance score to predict immune checkpoint inhibitor responses in melanoma patients.

Simultaneous, cell-intrinsic downregulation of PD-1 and TIGIT enhances the effector function of CD19-targeting CAR T cells and promotes an early-memory phenotype

This paper shows that simultaneously reducing PD-1 and TIGIT in CAR T cells improves their antitumor activity and memory phenotype in mouse models.

LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells

The paper shows that LPP3 is essential for melanoma cells to break down LPA, enabling self-generated chemotaxis and invasion.