Author

H. C. Kim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. H. Gundlach· 3 shared J. M. Craig· 3 shared J. R. Huang· 3 shared S. J. Abell· 3 shared A. H. Laszlo· 2 shared J. W. Mount· 2 shared M. De Jesus· 2 shared S. R. Torres· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

J. H. Gundlach

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Inhibition of the SARS-CoV-2 helicase at single-nucleotide resolution.

S. K. Marx, K. J. Mickolajczyk, J. M. Craig, C. A. Thomas, A. M. Pfeffer, S. J. Abell, J. D. Carrasco, M. C. Franzi, J. R. Huang, H. C. Kim, H. D. Brinkerhoff, T. M. Kapoor, J. H. Gundlach, A. H. Laszlo

This study uses nanopore tweezers to analyze SARS-CoV-2 helicase nsp13 motion and inhibition at single-nucleotide resolution, revealing kinetic mechanisms and inhibitor effects.

bioRxiv · Oct 7, 2022 · PreprintBiophysics

Sequence-dependent mechanochemical coupling of helicase translocation and unwinding at single-nucleotide resolution.

A. H. Laszlo, J. M. Craig, M. Gavrilov, R. Tippana, I. C. Nova, J. R. Huang, H. C. Kim, S. J. Abell, M. deCampos-Stairiker, J. W. Mount, J. L. Bowman, K. S. Baker, H. Higinbotham, D. Bobrovnikov, T. Ha, J. H. Gundlach

This study uses SPRNT to analyze how DNA sequence affects PcrA helicase kinetics during translocation and unwinding at single-nucleotide resolution.

bioRxiv · Feb 10, 2022Biophysics

Nanopore tweezers measurements of RecQ conformational changes reveal the energy landscape of helicase motion

J. M. Craig, M. Mills, A. Laszlo, H. C. Kim, S. J. Abell, J. R. Huang, J. W. Mount, K. C. Neuman, J. H. Gundlach

This study uses Nanopore Tweezers to measure RecQ helicase conformational changes, revealing an asymmetric energy landscape that allows it to maintain speed against opposing forces.

bioRxiv · Sep 23, 2021Biophysics

Cytoplasmic zinc regulates IL-1β production by monocytes/macrophages via mTORC1-induced glycolysis in rheumatoid arthritis (RA)

B. Kim, H. Y. Kim, B. R. Yoon, J. Yeo, K.-S. Yu, H. C. Kim, J. K. Park, S. W. Kang, W.-W. Lee

This study shows cytoplasmic zinc regulates IL-1β production in monocytes/macrophages through mTORC1-induced glycolysis by inhibiting PP2A.

bioRxiv · Apr 16, 2021 · PreprintImmunology

Simultaneous, cell-intrinsic downregulation of PD-1 and TIGIT enhances the effector function of CD19-targeting CAR T cells and promotes an early-memory phenotype

Y. Lee, H. J. Lee, H. C. Kim, Y. Lee, S. K. Nam, C. Hupperetz, J. S. Ma, X. Wang, O. Singer, W. S. Kim, S. J. Kim, Y. Koh, I. Jung, C. H. Kim

This paper shows that simultaneously reducing PD-1 and TIGIT in CAR T cells improves their antitumor activity and memory phenotype in mouse models.

bioRxiv · Nov 7, 2020 · PreprintImmunology

Assessment of Environmental and Occupational Exposure while Working with Candida auris a Multidrug Resistant (MDR) Fungus in the Animal Facility.

S. R. Torres, H. C. Kim, L. Leach, S. Chaturvedi, C. J. Bennett, D. J. Hill, M. De Jesus

This study assesses environmental and occupational exposure to Candida auris during animal facility work using murine models and finds dose-dependent shedding and effective mitigation strategies.

bioRxiv · Jan 4, 2019Microbiology

Setting off the Alarms: Candida albicans Elicits Pro-Inflammatory Differential Gene Expression in Intestinal Peyer’s Patches

N. Singh, H. C. Kim, R. Song, J. Dhinsa, S. R. Torres, M. De Jesus

This study shows that CD11c+ phagocytes in Peyer’s patches exhibit differential gene expression in response to Candida albicans, distinguishing between strains and contributing to mucosal barrier protection.

bioRxiv · Jan 4, 2019Microbiology