Acidic pH-dependent depletion of Mycobacterium tuberculosis thiol pools potentiates antibiotics and oxidizing agents
G. B. Coulson, B. K. Johnson, C. J. Colvin, R. J. Fillinger, H. Zheng, E. R. Haiderer, N. D. Hammer, R. B. Abramovitch
This study identifies AC2P36 as a compound that depletes Mtb thiol pools at acidic pH, enhancing sensitivity to antibiotics and oxidizing agents.
bioRxiv · Dec 21, 2016Microbiology