R. B. Abramovitch

Carbon dioxide regulates Mycobacterium tuberculosis PhoPR signaling and virulence

This study shows that CO2 regulates Mtb PhoPR signaling and virulence, with CanB playing a key role in virulence and CO2-dependent gene induction.

ppe51 variants promote non-replicating Mycobacterium tuberculosis to grow at acidic pH by selectively promoting glycerol uptake

This study identifies PPE51 variants that enhance glycerol uptake in Mycobacterium tuberculosis under acidic pH, promoting non-replicating growth and affecting macrophage virulence.

AC2P20 selectively kills M. tuberculosis at acidic pH by depleting free thiols

This study identifies AC2P20 as a compound that kills M. tuberculosis at acidic pH by depleting free thiols, supporting the role of redox homeostasis in Mtb survival.

Identification of new MmpL3 inhibitors by untargeted and targeted mutant screens defines MmpL3 domains with differential resistance

The paper identifies new MmpL3 inhibitors through screens and analyzes resistance mutations to define clades of inhibitors and mutants with differential resistance.

Inhibition of Mycobacterium tuberculosis DosRST two-component regulatory system signaling by targeting response regulator DNA binding and sensor kinase heme

This study identifies two inhibitors of the Mtb DosRST regulatory system, showing they target different components of the pathway and reduce hypoxia-induced persistence.

Genetic and metabolic regulation of Mycobacterium tuberculosis acid growth arrest

This study identifies genetic and metabolic mechanisms underlying Mycobacterium tuberculosis acid growth arrest, showing it is an adaptive process involving anaplerotic metabolism and PPE gene mutations.

Acidic pH-dependent depletion of Mycobacterium tuberculosis thiol pools potentiates antibiotics and oxidizing agents

This study identifies AC2P36 as a compound that depletes Mtb thiol pools at acidic pH, enhancing sensitivity to antibiotics and oxidizing agents.