Author

G. B. Coulson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

R. B. Abramovitch· 3 shared E. R. Haiderer· 2 shared B. K. Johnson· 1 shared C. Chen· 1 shared C. J. Colvin· 1 shared E. Ellsworth· 1 shared H. Zheng· 1 shared J. T. Williams· 1 shared

Activity by Year

2016-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

R. B. Abramovitch

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3 papers

Recent·Most cited

AC2P20 selectively kills M. tuberculosis at acidic pH by depleting free thiols

S. J. Dechow, G. B. Coulson, M. W. Wilson, S. D. Larsen, R. B. Abramovitch

This study identifies AC2P20 as a compound that kills M. tuberculosis at acidic pH by depleting free thiols, supporting the role of redox homeostasis in Mtb survival.

bioRxiv · Mar 16, 2021Microbiology

Identification of new MmpL3 inhibitors by untargeted and targeted mutant screens defines MmpL3 domains with differential resistance

J. T. Williams, E. R. Haiderer, G. B. Coulson, K. N. Conner, E. Ellsworth, C. Chen, T. Dick, R. B. Abramovitch

The paper identifies new MmpL3 inhibitors through screens and analyzes resistance mutations to define clades of inhibitors and mutants with differential resistance.

bioRxiv · Feb 28, 2019Microbiology

Acidic pH-dependent depletion of Mycobacterium tuberculosis thiol pools potentiates antibiotics and oxidizing agents

G. B. Coulson, B. K. Johnson, C. J. Colvin, R. J. Fillinger, H. Zheng, E. R. Haiderer, N. D. Hammer, R. B. Abramovitch

This study identifies AC2P36 as a compound that depletes Mtb thiol pools at acidic pH, enhancing sensitivity to antibiotics and oxidizing agents.

bioRxiv · Dec 21, 2016Microbiology