Structural basis for antagonism of the ubiquitin ligase BIRC6 by SMAC
L. Dietz, C. J. Ellison, C. Riechmann, C. K. Cassidy, F. D. Felfoldi, A. Pinto-Fernandez, B. M. Kessler, P. R. Elliott
This study reveals how SMAC antagonizes BIRC6 by binding multiple sites on BIRC6, displacing caspases and inhibiting its ubiquitin ligase activity.
bioRxiv · Aug 30, 2022 · PreprintBiochemistry