Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+ myeloid cells into the tumor microenvironment in a redundant manner
G. P. Takacs, C. J. Kreiger, D. Luo, G. Tian, J. S. Garcia, L. P. Deleyrolle, D. A. Mitchell, J. K. Harrison
This study shows that CCL2 and CCL7 from gliomas redundantly recruit CCR2+/CX3CR1+ myeloid cells into the tumor microenvironment, contributing to immune suppression and poor prognosis in GBM.
bioRxiv · Jul 8, 2022Cancer Biology