G. Tian

Serotonin Reuptake Inhibition Reduces NMDAR-Associated Reward Liability Without Compromising Rapid Antidepressant Efficacy

This study shows that combining serotonin reuptake inhibition with NMDAR antagonism reduces reward-related effects while maintaining rapid antidepressant efficacy.

The enzyme glutamate-cysteine ligase (GCL) is a target for ferroptosis induction in cancer

This study identifies GCL inhibition as a strategy to induce ferroptosis in cancer cells, introducing novel inhibitors with potent cellular activity.

KR158 spheres harboring slow-cycling cells recapitulate GBM features in an immunocompetent system

This study validates a murine model of glioblastoma stem cells that recapitulate human features and enables investigation of their interactions with the immune system.

NUCLEOPORIN1 mediates proteasome-based degradation of ABI5 to regulate Arabidopsis seed germination

This study identifies NUP1's role in Arabidopsis seed germination by mediating proteasome-dependent degradation of ABI5.

Tandemly duplicated MYB genes specifically in the Phaseoleae lineage are functionally diverged in the regulation of anthocyanin biosynthesis

The paper investigates functional divergence of tandemly duplicated MYB genes in soybean, showing they regulate anthocyanin biosynthesis differently in various tissues.

eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content

The paper identifies eIF3k as a regulator of ribosome content in cancer by showing its depletion increases global translation and stress resistance through repression of RPS15A synthesis.

NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma

The paper identifies NDC80 as a predictor of ccRCC progression and shows that NDC80-high tumors are sensitive to mitotic kinase inhibitors.

Matrix-seq: An adjustable-resolution spatial transcriptomics via microfluidic matrix-based barcoding.

Matrix-seq provides a microfluidic barcoding method for adjustable-resolution spatial transcriptomics, reducing technical barriers and enabling application in multiple biological fields.

Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+ myeloid cells into the tumor microenvironment in a redundant manner

This study shows that CCL2 and CCL7 from gliomas redundantly recruit CCR2+/CX3CR1+ myeloid cells into the tumor microenvironment, contributing to immune suppression and poor prognosis in GBM.

Slow-cycling cells in glioblastoma: a specific population in the cellular mosaic of cancer stem cells

This study compares slow-cycling cells with cancer stem cell (CSC)-like cells in glioblastoma, showing phenotypic and functional heterogeneity and supporting the cancer stem cell mosaicism model.

Allosteric control of Ubp6 and the proteasome via a bidirectional switch

This study identifies an allosteric switch that controls Ubp6 and the proteasome, showing their active states are mutually exclusive.

Effects of active dry yeast on growth performance, rumen fermentation characteristics and slaughter performance in beef cattle

This study examines how adding active dry yeast to the diet of beef cattle affects their growth, rumen fermentation, and slaughter performance, finding that 4 g/head/d improves microbial composition and carcass weight compared to low nutrition.

The DAXX-SREBP axis promotes oncogenic lipogenesis and tumorigenesis

This study identifies the DAXX-SREBP axis as a driver of lipogenesis and tumorigenesis by showing its role in activating lipogenic gene expression and promoting tumor growth.

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

Phosphatidylserine prevents the generation of a protein-free giant plasma membrane domain in yeast

The paper shows that yeast lacking phosphatidylserine form protein-free plasma membrane domains, termed void zones, which resemble artificial lipid domains.

eIF3 associates with 80S ribosomes to promote translation elongation, mitochondrial homeostasis, and muscle health

This study shows eIF3 interacts with 80S ribosomes to enhance early translation elongation of mRNAs involved in mitochondrial and membrane functions, critical for muscle health.

Three-dimensional Genome Structure Reveals Distinct Chromatin Signatures of Mouse Female Germline Stem Cells During Development

The paper examines the 3D chromatin structure of mouse female germline stem cells during development, identifying changes in TADs and conserved compartments related to imprinted genes.