Author

J. K. Harrison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

G. P. Takacs· 4 shared D. A. Mitchell· 2 shared G. Tian· 2 shared J. S. Garcia· 2 shared L. P. Deleyrolle· 2 shared A. Chakraborty· 1 shared A. Sharma· 1 shared A. Sherman· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersCancer Biology

G. P. Takacs

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Author profile →

5 papers

Recent·Most cited

DR5 disulfide bonding as a sensor and effector of protein folding stress

M. E. Law, Z. M. Dulloo, S. R. Eggleston, G. P. Takacs, G. M. Alexandrow, M. Wang, H. Su, B. A. Forsyth, C.-W. Chiang, A. Sharma, S. R. R. Kanumuri, O. A. Guryanova, J. K. Harrison, B. Tirosh, R. K. Castellano, B. K. Law

This study shows that disrupting DR5 disulfide bonds activates pro-apoptotic signaling and reveals DR5 disulfide bonding as a sensor and effector of ER stress in cancer cells.

bioRxiv · Mar 4, 2024 · PreprintCancer Biology

Systemically targeting monocytic MDSCs using dendrimers and their cell-level biodistribution kinetics

C. A. Littrell, G. P. Takacs, C. Siva Sankara, A. Sherman, K. A. Rubach, J. S. Garcia, C. Bell, J. K. Harrison, F. Zhang

This study examines how hydroxyl dendrimers are taken up by M-MDSCs in tumor and lymphoid organs, showing differential uptake based on dendrimer functionality and serum proteins.

bioRxiv · Feb 14, 2024 · PreprintBioengineering

KR158 spheres harboring slow-cycling cells recapitulate GBM features in an immunocompetent system

A. Chakraborty, C. Yang, J. L. Kresak, A. Silver, D. Feier, G. Tian, M. Andrews, O. O. Sobanjo, O. O. Sobanjo, E. D. Hodge, M. K. Engelbart, J. Huang, J. K. Harrison, M. Sarkisian, D. A. Mitchell, L. P. Deleyrolle

This study validates a murine model of glioblastoma stem cells that recapitulate human features and enables investigation of their interactions with the immune system.

bioRxiv · Jan 26, 2024 · PreprintCancer Biology

Global stability and parameter analysis reinforce therapeutic targets of PD-L1-PD-1 and MDSCs for glioblastoma

H. G. Anderson, G. P. Takacs, D. C. Harris, Y. Kuang, J. K. Harrison, T. L. Stepien

This paper develops a tumor-immune model for glioblastoma, identifies key parameters for treatment, and suggests combining immune checkpoint inhibitors with MDSC-targeting therapies.

bioRxiv · May 15, 2023Cancer Biology

Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+ myeloid cells into the tumor microenvironment in a redundant manner

G. P. Takacs, C. J. Kreiger, D. Luo, G. Tian, J. S. Garcia, L. P. Deleyrolle, D. A. Mitchell, J. K. Harrison

This study shows that CCL2 and CCL7 from gliomas redundantly recruit CCR2+/CX3CR1+ myeloid cells into the tumor microenvironment, contributing to immune suppression and poor prognosis in GBM.

bioRxiv · Jul 8, 2022Cancer Biology