Author

C. Kee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. Boulant· 4 shared C. Herrmann· 2 shared C. Ramirez· 2 shared M. L. Stanifer· 2 shared P. Doldan· 2 shared S. Triana· 2 shared T. Alexandrov· 2 shared A. Kumar Sharma· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersImmunology

S. Boulant

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Increased sensitivity of SARS-CoV-2 to type III interferon in human intestinal epithelial cells

C. Kee, C. Metz-Zumaran, P. Doldan, C. Guo, M. Stanifer, S. Boulant

This study shows that type III interferons are more effective than type I interferons in reducing SARS-CoV-2 infection in human intestinal epithelial cells.

bioRxiv · Jun 14, 2021 · PreprintImmunology

SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity

C. Ramirez, A. Kumar Sharma, C. Kee, L. Thomas, S. Boulant, C. Herrmann

This study identifies SPINT2 as a regulator of SARS-CoV-2 infection, showing its negative correlation with viral expression and down-regulation in COVID-19 patients and chronic disease datasets.

bioRxiv · Dec 28, 2020 · PreprintCell Biology

Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut

S. Triana, C. Metz Zumaran, C. Ramirez, C. Kee, P. Doldan, M. Shahraz, D. Schraivogel, A. R. Gschwind, L. M. Steinmetz, C. Herrmann, T. Alexandrov, S. Boulant, M. L. Stanifer

This study identifies enterocytes as the main target of SARS-CoV-2 in the gut and shows the virus suppresses interferon signaling to evade immune response.

bioRxiv · Oct 21, 2020Immunology

Critical role of type III interferon in controlling SARS-CoV-2 infection, replication and spread in primary human intestinal epithelial cells

M. L. Stanifer, C. Kee, M. Cortese, S. triana, M. Mukenhirn, H.-G. Kraeusslich, T. Alexandrov, R. Bartenschlager, S. Boulant

This study shows that human intestinal epithelial cells support SARS-CoV-2 infection and replication, with type III interferon more effective than type I in controlling viral spread.

bioRxiv · Apr 24, 2020 · PreprintMicrobiology