Author

C. L. Gilchrist

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

E. C. Dueber· 1 shared E. Helgason· 1 shared H. Hamidi· 1 shared I. E. Wertz· 1 shared L. R. Kenner· 1 shared M. Hafner· 1 shared N. Endres· 1 shared R. Piskol· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

E. C. Dueber

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1 paper

Recent·Most cited

Constitutive protein degradation induces acute cell death via proteolysis products

S.-H. Chen, S. Prakash, E. Helgason, C. L. Gilchrist, L. R. Kenner, R. Srinivasan, T. Sterne-Weiler, M. Hafner, R. Piskol, E. C. Dueber, H. Hamidi, N. Endres, X. Ye, W. J. Fairbrother, I. E. Wertz

This study shows proteasome-generated peptides from degraded proteins induce cell death by neutralizing IAPs, explaining the efficacy of proteolysis-modulating drugs like thalidomide analogs and bortezomib.

bioRxiv · Feb 6, 2023 · PreprintCell Biology