Author

C. L. Vizcarra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:mouse· 3 Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Organism:human· 1

Frequent Co-Authors

C. Hachicho· 2 shared M. E. Quinlan· 2 shared R. Lakha· 2 shared A. Klestzick· 1 shared A. M. Montero· 1 shared A. O. Bradley· 1 shared A. Oza· 1 shared C. C. Costeas· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

C. Hachicho

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Author profile →

5 papers

Recent·Most cited

Metallothionein-3 attenuates the effect of Cu2+ ions on actin filaments

R. Lakha, C. Hachicho, M. R. Mehlenbacher, D. E. Wilcox, R. N. Austin, C. L. Vizcarra

This study shows that MT-3 does not directly bind actin but reduces Cu2+-induced actin filament fragmentation by chelating Cu2+.

bioRxiv · Sep 23, 2022Biochemistry

Alterations to the broad-spectrum formin inhibitor SMIFH2 improve potency

M. Orman, M. Landis, A. Oza, D. Nambiar, J. Gjeci, K. Song, V. Huang, A. Klestzick, C. Hachicho, S. Q. Liu, J. M. Kamm, F. Bartolini, J. J. Vadakkan, C. M. Rojas, C. L. Vizcarra

The paper tests SMIFH2 and its derivatives against human formins, finding that modifications enhance potency but do not allow distinction between conserved FH2 domains.

bioRxiv · Mar 10, 2022 · PreprintBiochemistry

Variable autoinhibition among deafness-associated variants of Diaphanous 1 (DIAPH1)

R. Lakha, A. M. Montero, T. Jabeen, C. C. Costeas, J. Ma, C. L. Vizcarra

This study investigates how deafness-associated DIAPH1 mutations affect autoinhibition and actin assembly, finding variable disruption of autoinhibition among mutants.

bioRxiv · Mar 10, 2021Biochemistry

Spire stimulates nucleation by Cappuccino and binds both ends of actin filaments

A. O. Bradley, C. L. Vizcarra, H. M. Bailey, M. E. Quinlan

The paper shows Spire and Cappuccino collaborate to synergistically nucleate actin filaments in oocytes, with Spire binding both ends of actin filaments.

bioRxiv · Sep 18, 2019Biochemistry

The Neuron Specific Formin Delphilin Nucleates Actin Filaments but Does Not Enhance Elongation

W. T. Silkworth, K. L. Kunes, G. C. Nickel, M. L. Phillips, M. E. Quinlan, C. L. Vizcarra

This study investigates the actin assembly properties of the neuron-specific formin Delphilin, finding it nucleates actin filaments without enhancing elongation and shows preference for specific actin isoforms.

bioRxiv · Jun 16, 2017Biochemistry