Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
J. Li, Y. Fukase, Y. Shang, W. Zou, J. Munoz-Felix, L. Buitrago, J. van Agthoven, Y. Zhang, R. Hara, Y. Tanaka, R. Okamoto, T. Yasui, T. Nakahata, T. Imaeda, K. Aso, , B. S. Coller
This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.
bioRxiv · May 24, 2019Pharmacology & Toxicology