Author

Y. Fukase

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

B. S. Coller· 1 shared C. C. Santarossa· 1 shared C. Locuson· 1 shared D. C. Ekiert· 1 shared D. Nesic· 1 shared G. Bhabha· 1 shared J. B. Steinman· 1 shared J. Li· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

B. S. Coller

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Targeting Allostery in the Dynein Motor Domain with Small Molecule Inhibitors

C. C. Santarossa, K. Mickolajczyk, J. B. Steinman, L. Urnavicius, N. Chen, Y. Fukase, Y. Hirata, N. Coudray, D. C. Ekiert, G. Bhabha, T. M. Kapoor

This study develops small molecule inhibitors targeting allostery in dynein motor domains by inhibiting regulatory ATPase sites rather than the main catalytic site.

bioRxiv · Sep 22, 2020Biochemistry

Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

J. Li, Y. Fukase, Y. Shang, W. Zou, J. Munoz-Felix, L. Buitrago, J. van Agthoven, Y. Zhang, R. Hara, Y. Tanaka, R. Okamoto, T. Yasui, T. Nakahata, T. Imaeda, K. Aso, , B. S. Coller

This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.

bioRxiv · May 24, 2019Pharmacology & Toxicology