Y. Tanaka

The Rubicon-WIPI axis regulates exosome biogenesis during aging

This study identifies the Rubicon-WIPI axis as a regulator of exosome biogenesis, showing its role in age-dependent exosome release and microRNA fate in mice.

A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

This paper identifies a heterocyclic compound, HT-7, that inhibits HIV-1 release by increasing cell surface BST2 expression with minimal cellular toxicity.

Structural basis for bispecific antibody design: arrangement of domain linkage produces activity enhancement

This study determines the cryo-EM structures of two bispecific antibody types and shows that domain linkage rearrangement leads to activity enhancement by altering complex shape and dynamics.

A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

DERIVATION OF ELEPHANT INDUCED PLURIPOTENT STEM CELLS

This paper reports the first derivation of elephant induced pluripotent stem cells (emiPSCs) using a modified reprogramming protocol that inhibits TP53 expansion genes.

Discovery of N-Glycan Outer Chain like α-(1->6)-linked Mannan Structures in Aspergillus fumigatus Mycelium

This study identifies novel -(1->6)-linked mannan structures in Aspergillus fumigatus mycelium and characterizes the enzymes involved in their biosynthesis.

IGSF3 is a homophilic cell adhesion molecule that drives lung metastasis of melanoma by promoting adhesion to vascular endothelium

NEDD4-binding protein 1 suppresses HBV replication by degrading HBV RNAs

This paper identifies N4BP1 as a host factor that suppresses HBV replication by degrading HBV RNAs, with its KH-like and RNase domains required for this effect.

Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium

The paper identifies a developmental pathway where CCL21-expressing thymic epithelial cells convert into self-antigen-displaying cells, contributing to functional diversity in the thymus medulla.

Pigmentation level of human iPSC-derived retinal pigment epithelium cell does not indicate a specific gene expression profile

The paper analyzes the relationship between pigmentation level and gene expression in human iPSC-derived RPE cells, finding no specific gene expression profile correlates with color intensity.

The D-mannose/L-galactose pathway plays a predominant role in ascorbate biosynthesis in the liverwort Marchantia polymorpha but is not regulated by light and oxidative stress

Structure and function of bacterial YeeE-YeeD complex in thiosulfate uptake pathway

This study investigates the YeeE-YeeD complex in thiosulfate uptake, showing YeeD's role in transport and decomposition, and presents their structural interactions.

Metabolic regulation in erythroid differentiation by systemic ketogenesis in fasted mice

This study shows that reduced systemic ketogenesis in fasted mice enhances erythroid maturation by boosting fatty acid synthesis and mevalonate pathway with decreased histone acetylation.

Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation for analyzing extracellular viral markers

This study develops a multiscale mathematical model to predict intrahepatic cccDNA dynamics using serum viral markers, offering a non-invasive method for HBV infection analysis.

Dose-response relationship for the resistance of human insulin to degradation by insulin-degrading enzyme

The paper investigates how human insulin resistance to degradation by IDE varies with dose and identifies structural features of the insulin hexamer that influence degradation kinetics without zinc.

Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis

This study identifies PFKFB3 as a key regulator of glycolytic metabolism in HSCs under stress, showing its context-dependent activation promotes ATP production and hematopoiesis.

Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis

The paper investigates silica-induced pulmonary fibrosis in mice, finding that silica triggers osteoclast-like differentiation of macrophages and monocytes, contributing to lung injury and fibrosis.

Dynamics and consequences of the HTLV-1 proviral plus-strand burst

This study uses live-cell imaging and mathematical modeling to analyze Tax expression dynamics in HTLV-1 infected T-cells, revealing heterogeneous patterns and impacts on cell behavior.

Prediction of elimination of intrahepatic cccDNA in hepatitis B virus-infected patients by a combination of noninvasive viral markers

This study develops a noninvasive method using viral markers to predict cccDNA levels in HBV patients, validated against liver biopsy data.

Inhibition of the BMP pathway suppresses tumor growth via downregulation of EGFR in MEK/ERK-dependent colorectal cancer

This study shows that inhibiting the BMP pathway suppresses colorectal cancer growth by reducing EGFR, and combining BMP and MEK inhibition enhances therapeutic effects in patient-derived organoids.

Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

This paper quantitatively analyzes calcium oxalate monohydrate and dihydrate in kidney stones using FTIR, PXRD, and micro-CT to understand their formation mechanisms.

Murine breast cancers disorganize the liver transcriptome in zonated manners

This study uses spatial transcriptomics to show that breast cancers disrupt liver zonation patterns, affecting specific metabolic and immune pathways in a zonated manner.

Cryptic functional diversity in ant tandem runs

This study identifies functional differences in tandem running between two ant genera by analyzing recruitment networks and information flow.

Mechano-inhibition of Endocytosis Sensitizes Cancer Cells to Fas-induced Apoptosis

The paper shows that inhibiting endocytosis with fasudil increases Fas microaggregate formation, making cancer cells more sensitive to FasL-induced apoptosis.

Morphological evolution and diversity of pectoral fin skeletons in teleosts

The paper compares pectoral fin skeletons across 27 teleost species to identify morphological variations and evolutionary patterns.

Time-course of host cell transcription during the HTLV-1 transcriptional burst

This study examines how HTLV-1 transcriptional bursts affect host transcription over time in infected T-cells, finding transient activation of pathways like NF-κB and clone-specific differences in cell cycle regulation.

Quantitative live-cell imaging of secretion activity reveals dynamic immune responses

This paper introduces qLCI-S, a method for quantitative live-cell imaging of secretion activity, enabling single-cell analysis of cytokine secretion and transcriptome profiling of rare cell populations.

Cell viability assessment associated with a contact of gas bubbles produced by femtosecond laser breakdown in cell culture media

This study examines the effects of gas bubbles from femtosecond laser processing on cell viability, finding that stable bubbles do not harm cells but bubble bursts can cause mechanical damage.

Estimation of the reference lead (Pb) concentration levels affecting immune cells in the blood of Black-headed Gulls (Chroicocephalus ridibundus, Laridae)

Distinct and interchangeable growing patterns in colorectal cancer stem-like cells are regulated by Musashi-1

The paper identifies distinct growth patterns in colorectal cancer stem-like cells and shows Musashi-1 regulates their plasticity and drug resistance.