Author

C. M. Hurley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Li· 2 shared E. J. Petersson· 2 shared M. B. Cory· 2 shared R. M. Kohli· 2 shared Y. Venkatesh· 2 shared Z. M. Hostetler· 2 shared A. Bashyal· 1 shared C. M. Jones· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

A. Li

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3 papers

Recent·Most cited

The LexA-RecA* structure reveals a lock-and-key mechanism for SOS activation

M. B. Cory, A. Li, C. M. Hurley, P. J. Carman, R. A. Pumroy, Z. M. Hostetler, Y. Venkatesh, K. B. Gupta, E. J. Petersson, R. M. Kohli

The paper determines the structure of the LexA-RecA* complex, revealing a lock-and-key mechanism that triggers SOS response gene induction by enabling LexA cleavage.

bioRxiv · Oct 30, 2023 · PreprintBiochemistry

Engineered RecA constructs reveal the minimal SOS activation complex

M. B. Cory, A. Li, C. M. Hurley, Z. M. Hostetler, Y. Venkatesh, C. M. Jones, E. J. Petersson, R. M. Kohli

This study identifies the minimal RecA* filament required for LexA cleavage by showing that three linked RecA units can bind ssDNA and trigger LexA degradation.

bioRxiv · Sep 30, 2022Biochemistry

Ubiquitin receptors are required for substrate-mediated activation of the proteasome’s unfolding ability

M. D. Cundiff, C. M. Hurley, J. D. Wong, A. Bashyal, J. Rosenberg, E. L. Reichard, N. D. Nassif, J. Brodbelt, D. Kraut

This study identifies ubiquitin receptors as essential for substrate-mediated activation of the proteasome's unfolding ability, with Rpn13 playing the largest role.

bioRxiv · Mar 28, 2019Biochemistry