Author

J. Rosenberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. Tian· 2 shared E. B. Chang· 2 shared J. Huang· 2 shared J. Shi· 2 shared M. Chen· 2 shared P. Penaloza-MacMaster· 2 shared X. Cai· 2 shared A. A. Tu· 1 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersBioengineering

B. Tian

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Nanotraps for the containment and clearance of SARS-CoV-2

M. Chen, J. Rosenberg, X. Cai, A. C. H. Lee, J. Shi, M. Nguyen, T. Wignakumar, V. Mirle, A. J. Edobor, J. Fung, J. S. Donington, K. Shanmugarajah, E. B. Chang, G. Randall, P. Penaloza-MacMaster, , J. Huang

This paper introduces Nanotraps, functionalized nanoparticles that block SARS-CoV-2 infection by inhibiting spike protein-ACE2 interaction and triggering macrophage-mediated viral clearance.

bioRxiv · Feb 1, 2021Bioengineering

A Neutralizing Antibody-Conjugated Photothermal Nanoparticle Captures and Inactivates SARS-CoV-2

X. Cai, A. Prominski, Y. Lin, N. Ankenbruck, J. Rosenberg, M. Chen, J. Shi, E. B. Chang, P. Penaloza-MacMaster, B. Tian, J. Huang

This paper develops a photothermal nanoparticle conjugated with neutralizing antibodies to capture and inactivate SARS-CoV-2, showing efficient viral capture, photothermal effect, and inhibition of viral entry.

bioRxiv · Nov 30, 2020 · PreprintBioengineering

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

H. P. Gideon, T. K. Hughes, C. N. Tzouanas, M. H. Wadsworth, A. A. Tu, T. M. Gierahn, J. M. Peters, F. H. Hopkins, J.-R. Wei, C. Kummerlowe, N. L. Grant, K. Nargan, J. Phuah, H. J. Borish, P. Maiello, , A. K. Shalek

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

bioRxiv · Oct 24, 2020 · PreprintImmunology

A systems-biology approach to molecular machines: Exploration of alternative transporter mechanisms

A. George, P. Bisignano, J. Rosenberg, M. Grabe, D. M. Zuckerman

This paper introduces a computational method to explore alternative mechanisms of molecular machines, finding diverse reaction pathways for cotransport with proofreading capabilities.

bioRxiv · Jan 7, 2020Biophysics

Ubiquitin receptors are required for substrate-mediated activation of the proteasome’s unfolding ability

M. D. Cundiff, C. M. Hurley, J. D. Wong, A. Bashyal, J. Rosenberg, E. L. Reichard, N. D. Nassif, J. Brodbelt, D. Kraut

This study identifies ubiquitin receptors as essential for substrate-mediated activation of the proteasome's unfolding ability, with Rpn13 playing the largest role.

bioRxiv · Mar 28, 2019Biochemistry

A Multifactorial Model of T Cell Expansion and Durable Clinical Benefit in Response to a PD-L1 Inhibitor

M. D. Leiserson, V. Syrgkanis, A. Gilson, M. Dudik, S. Gillett, J. Chayes, C. Borgs, D. F. Bajorin, J. Rosenberg, S. Funt, A. Snyder, L. Mackey

This paper develops a multifactorial model to predict T cell expansion and clinical benefit from PD-L1 inhibitors using clinical, tumor, and circulating features, showing improved accuracy over single biomarkers.

bioRxiv · Apr 10, 2018Cancer Biology