Author

R. A. Pumroy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 3 Research Focus:protein structure prediction· 3 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Samanta· 2 shared K. W. Huynh· 2 shared T. E. T. Hughes· 2 shared T. Rohacs· 2 shared V. Y. Moiseenkova-Bell· 2 shared Z. H. Zhou· 2 shared A. D. Protopopova· 1 shared A. Leffler· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiophysics

A. Samanta

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Author profile →

4 papers

Recent·Most cited

The LexA-RecA* structure reveals a lock-and-key mechanism for SOS activation

M. B. Cory, A. Li, C. M. Hurley, P. J. Carman, R. A. Pumroy, Z. M. Hostetler, Y. Venkatesh, K. B. Gupta, E. J. Petersson, R. M. Kohli

The paper determines the structure of the LexA-RecA* complex, revealing a lock-and-key mechanism that triggers SOS response gene induction by enabling LexA cleavage.

bioRxiv · Oct 30, 2023 · PreprintBiochemistry

TRPV2 interaction with small molecules and lipids revealed by cryo-EM

A. D. Protopopova, R. A. Pumroy, J. de la Roche, F. M. Haug, B. B. Sousa, P. N. Gallo, G. J. L. Bernardes, A. Leffler, V. Moiseenkova-Bell

This study reveals TRPV2 structures bound to small molecules and lipids using cryo-EM, identifying new binding sites and mechanisms of channel gating.

bioRxiv · Aug 10, 2020 · PreprintBiophysics

Molecular mechanism of TRPV2 channel modulation by cannabidiol

R. A. Pumroy, A. Samanta, Y. Liu, T. E. T. Hughes, S. Zhao, Y. Yudin, K. W. Huynh, Z. H. Zhou, T. Rohacs, S. Han, V. Y. Moiseenkova-Bell

This study determines the structure of TRPV2 bound to cannabidiol, revealing a unique binding site and the role of the S4-S5 linker in channel gating.

bioRxiv · May 24, 2019Biophysics

Structural insights on TRPV5 gating by endogenous modulators

T. E. T. Hughes, R. A. Pumroy, A. T. Yazici, M. A. Kasimova, E. C. Fluck, K. W. Huynh, A. Samanta, S. Molugu, Z. H. Zhou, V. Carnevale, T. Rohacs, V. Y. Moiseenkova-Bell

The paper determines TRPV5 structures with endogenous modulators PI(4,5)P2 and CaM, revealing their mechanisms of activation and inhibition.

bioRxiv · Jul 31, 2018Biophysics