Author

C. Machahua

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:mouse· 1

Frequent Co-Authors

B. Zumkehr· 2 shared M. Funke-Chambour· 2 shared M. P. Alves· 2 shared P. Dorn· 2 shared V. Thiel· 2 shared A. Breithaupt· 1 shared A. Godel· 1 shared A. Kratzel· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

B. Zumkehr

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Author profile →

2 papers

Recent·Most cited

Aging shapes infection profiles of influenza A virus and SARS-CoV-2 in human lung slices

M. Bruegger, C. Machahua, B. Zumkehr, C. Cismaru, D. Jandrasits, P. Dorn, T. Marti, G. Zimmer, V. Thiel, M. Funke-Chambour, M. P. Alves

This study shows that aged lung tissue reduces viral replication of IAV and SARS-CoV-2 but increases inflammatory responses, suggesting immune dysregulation contributes to severe disease.

bioRxiv · Apr 14, 2024 · PreprintMicrobiology

The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

T. Barut, N. J. Halwe, A. Taddeo, J. N. Kelly, J. Schön, N. Ebert, L. Ulrich, C. Devisme, S. Steiner, B. S. Trueeb, B. Hoffmann, I. B. Veiga, N. F. G. Leborgne, E. A. Moreira, A. Breithaupt, , V. Thiel

This study shows the spike gene determines replication, pathogenicity, and immune evasion of SARS-CoV-2 Omicron-BA.1 compared to Delta in cell cultures and animal models.

bioRxiv · Apr 28, 2022Microbiology