G. Zimmer

Aging shapes infection profiles of influenza A virus and SARS-CoV-2 in human lung slices

This study shows that aged lung tissue reduces viral replication of IAV and SARS-CoV-2 but increases inflammatory responses, suggesting immune dysregulation contributes to severe disease.

Intramuscular prime/intranasal boost vaccination to induce sterilizing immunity against influenza A virus infection

This paper develops an intramuscular prime/intranasal boost vaccination strategy against influenza A virus that achieves sterilizing immunity in pigs by combining a propagation-defective RNA vector with a modified live-attenuated vaccine.

Non-neutralizing antibody responses to vesicular stomatitis virus-vectored influenza A virus vaccines correlate with protection

This study shows that non-neutralizing antibodies against conserved IAV antigens like NP and M2 provide cross-protection against different IAV strains in mice.

Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior protective humoral immune response to SARS-CoV-2

This study shows that VSV-vectored spike protein vaccines induce protective immunity when trans-complemented with VSV glycoprotein, but do not achieve sterilizing immunity against SARS-CoV-2.

A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets

This study identifies autophagy-related host factors as conserved targets for coronavirus replication using CRISPR screens and shows that immunophilin inhibitors can block viral replication.

No evidence for human monocyte-derived macrophage infection and antibody-mediated enhancement of SARS-CoV-2 infection

This study shows SARS-CoV-2 and SARS-CoV-1 do not infect human macrophages or induce inflammation, and patient serum does not enhance infection or trigger immune responses in these cells.

Biparatopic sybody constructs neutralize SARS-CoV-2 variants of concern and mitigate emergence of drug resistance

LY6E impairs coronavirus fusion and confers immune control of viral disease

This study identifies LY6E as an interferon-induced gene that restricts coronavirus entry and pathogenesis by inhibiting spike protein-mediated fusion and protecting immune cells.

T-cell immunoglobulin and mucin (TIM) contributes to Hantaan virus entry into human airway epithelial cells

This study identifies TIM family proteins as PS receptors for HTNV and ANDV entry into human airway epithelial cells, revealing apoptotic mimicry as a mechanism for viral entry.