M. Bruegger

Aging shapes infection profiles of influenza A virus and SARS-CoV-2 in human lung slices

This study shows that aged lung tissue reduces viral replication of IAV and SARS-CoV-2 but increases inflammatory responses, suggesting immune dysregulation contributes to severe disease.

The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis

This study investigates how the developing T cell compartment in neonatal lungs influences RSV immunopathogenesis, finding that baseline type 2 responses and regulatory T cell activity are key factors in disease severity.