Author

M. P. Alves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. Zumkehr· 4 shared N. Ruggli· 3 shared A. Fahmi· 2 shared A. Summerfield· 2 shared A. Taddeo· 2 shared B. Oliveira Esteves· 2 shared C. Benarafa· 2 shared C. Machahua· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

B. Zumkehr

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Aging shapes infection profiles of influenza A virus and SARS-CoV-2 in human lung slices

M. Bruegger, C. Machahua, B. Zumkehr, C. Cismaru, D. Jandrasits, P. Dorn, T. Marti, G. Zimmer, V. Thiel, M. Funke-Chambour, M. P. Alves

This study shows that aged lung tissue reduces viral replication of IAV and SARS-CoV-2 but increases inflammatory responses, suggesting immune dysregulation contributes to severe disease.

bioRxiv · Apr 14, 2024 · PreprintMicrobiology

Monkeypox virus spreads from cell-to-cell and leads to neuronal death in human neural organoids

I. Schultz-Pernice, A. Fahmi, F. Britto, M. Liniger, Y.-C. Chiu, T. David, B. I. Oliveira Esteves, A. Golomingi, B. Zumkehr, M. Gerber, D. Jandrasits, R. Zuest, S. Steiner, C. Wotzkow, F. Blank, , M. P. Alves

This study shows MPXV spreads cell-to-cell in human neural organoids, causing neuronal death and neuritic bead formation, and identifies tecovirimat as effective in reducing viral load.

bioRxiv · Sep 19, 2023Microbiology

The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

T. Barut, N. J. Halwe, A. Taddeo, J. N. Kelly, J. Schön, N. Ebert, L. Ulrich, C. Devisme, S. Steiner, B. S. Trueeb, B. Hoffmann, I. B. Veiga, N. F. G. Leborgne, E. A. Moreira, A. Breithaupt, , V. Thiel

This study shows the spike gene determines replication, pathogenicity, and immune evasion of SARS-CoV-2 Omicron-BA.1 compared to Delta in cell cultures and animal models.

bioRxiv · Apr 28, 2022Microbiology

Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection

M. Brugger, T. Demoulins, G. T. Barut, B. Zumkehr, B. Oliveira Esteves, K. Mehinagic, Q. Haas, A. Schogler, M.-A. Rameix-Welti, J.-F. Eleouet, U. Moehrlen, T. Marti, R. Schmid, A. Summerfield, H. Posthaus, , M. P. Alves

The paper investigates the role of lung-resident mesenchymal stem cells in the host response to RSV infection, showing their activation and involvement in antiviral, inflammatory, and repair processes.

bioRxiv · May 12, 2021Microbiology

The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis

T. Demoulins, M. Bruegger, B. Zumhehr, B. Oliveira Esteves, K. Mehinagic, A. Fahmi, L. Borcard, A. Taddeo, H. Posthaus, C. Benarafa, N. Ruggli, M. P. Alves

This study investigates how the developing T cell compartment in neonatal lungs influences RSV immunopathogenesis, finding that baseline type 2 responses and regulatory T cell activity are key factors in disease severity.

bioRxiv · Aug 14, 2020Immunology