Author

C. Markouli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Keller· 3 shared C. Spits· 3 shared D. Dziedzicka· 3 shared E. Couvreu De Deckersberg· 3 shared M. Geens· 3 shared K. Sermon· 2 shared S. Franck· 2 shared A. Gheldof· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCell Biology

A. Keller

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Author profile →

3 papers

Recent·Most cited

Gains of 12p13.31 delay WNT-mediated initiation of hPSC differentiation and promote residual pluripotency in a cell cycle dependent manner

A. Keller, Y. Lei, N. Krivec, E. Couvreu De Deckersberg, D. Dziedzicka, C. Markouli, K. D. Sermon, M. Geens, C. Spits

This study shows that gains of 12p13.31 in hPSC delay WNT signaling and promote residual pluripotency through NANOG and GDF3, dependent on cell cycle position during differentiation.

bioRxiv · May 22, 2021 · PreprintCell Biology

Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

D. Dziedzicka, M. Tewary, A. Keller, L. Tilleman, L. Prochazka, J. Östblom, E. Couvreu De Deckersberg, C. Markouli, S. Franck, F. Van Nieuwerburgh, C. Spits, P. W. Zandstra, K. Sermon, M. Geens

The paper shows that endogenous suppression of WNT signaling in hPSCs reduces differentiation efficiency towards definitive endoderm, and that increasing WNT or inhibiting PI3K/AKT can overcome this block.

bioRxiv · Jul 3, 2020Cell Biology

Constitutional activation of BMP4 and WNT signalling in hESC results in impaired mesendoderm differentiation

C. Markouli, E. Couvreu De Deckersberg, D. Dziedzicka, M. Regin, S. Franck, A. Keller, A. Gheldof, M. Geens, K. Sermon, C. Spits

The paper identifies a human embryonic stem cell subline with hyperactivated WNT and BMP4 signaling that impairs mesendoderm differentiation, leading to trophoblast-like cell formation.

bioRxiv · Jun 4, 2020 · PreprintCell Biology