Author

L. Tilleman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

F. Van Nieuwerburgh· 5 shared F. Speleman· 3 shared K. Durinck· 3 shared A. Eggermont· 2 shared B. Decaesteker· 2 shared C. Van Neste· 2 shared D. Deforce· 2 shared E. Sanders· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

F. Van Nieuwerburgh

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The fork restart factor PHF6 interacts with RRM2 and binds to H3K56ac marked nascent DNA

L. Depestel, S.-L. Bekaert, E. Sanders, C. Van Damme, A. Eggermont, S. Loontiens, L. Tilleman, F. Van Nieuwerburgh, L. Delhaye, P. Van Vlierberghe, S. Eyckerman, F. Speleman, K. Durinck

This study identifies PHF6's interaction with RRM2 and its binding to H3K56ac marked nascent DNA, revealing a role in replication fork restart and DNA damage repair.

bioRxiv · Mar 8, 2023 · PreprintCancer Biology

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

S. Zanotti, S. Vanhauwaert, C. Van Neste, V. Olexiouk, J. Van Laere, M. Verschuuren, L. M. Mus, K. Durinck, L. Tilleman, D. Deforce, F. Van Nieuwerburgh, M. D. Hogarty, B. Decaesteker, W. H. De Vos, F. Speleman

This study shows that MYCN activation in RPE cells causes nucleolar stress and a senescence-like transcriptional program without full senescence hallmarks, leading to growth attenuation.

bioRxiv · Jan 22, 2021Cancer Biology

RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

C. Nunes, L. Depestel, L. M. Mus, K. M. Keller, L. Delhaye, A. Louwagie, M. Rishfi, E. M. Dolman, V. Olexiouk, C. Bartenhagen, F. Devloed, E. Sanders, A. Eggermont, J. Van Laere, E. De Smet, , F. Speleman

This study identifies RRM2 as a therapeutic target in high-risk neuroblastoma, showing that combined RRM2 and CHK1 inhibition synergistically reduces tumor growth.

bioRxiv · Nov 25, 2020 · PreprintCancer Biology

Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

D. Dziedzicka, M. Tewary, A. Keller, L. Tilleman, L. Prochazka, J. Östblom, E. Couvreu De Deckersberg, C. Markouli, S. Franck, F. Van Nieuwerburgh, C. Spits, P. W. Zandstra, K. Sermon, M. Geens

The paper shows that endogenous suppression of WNT signaling in hPSCs reduces differentiation efficiency towards definitive endoderm, and that increasing WNT or inhibiting PI3K/AKT can overcome this block.

bioRxiv · Jul 3, 2020Cell Biology

Positive human health effects of sea spray aerosols: molecular evidence from exposed lung cell lines.

J. Asselman, E. Van Acker, M. De Rijcke, L. Tilleman, F. Van Nieuwerburgh, J. Mees, K. De Schamphelaere, C. Janssen

The paper exposes lung cells to sea spray aerosols and finds positive molecular effects on the mTOR pathway and PCSK9 at environmentally relevant concentrations.

bioRxiv · Aug 23, 2018Pharmacology & Toxicology