F. Van Nieuwerburgh

A spatial human thymus cell atlas mapped to a continuous tissue axis

The paper maps the spatial organization of the human thymus across developmental stages using a multimodal atlas and identifies key cellular and molecular features of T cell development.

Non-random polymorphisms near transposable elements facilitate evolution across the genome of Arabidopsis thaliana

This study analyzes 973 Arabidopsis thaliana genomes to show that transposable elements (TEs) drive non-random genetic variation and contribute to evolutionary potential despite self-fertilization.

Myeloid A20 is critical for type-2 immune mediated helminth resistance

This study identifies A20 as an essential myeloid factor for inducing type-2 immune responses against Trichuris muris, with its loss leading to chronic infection and inflammation.

The fork restart factor PHF6 interacts with RRM2 and binds to H3K56ac marked nascent DNA

This study identifies PHF6's interaction with RRM2 and its binding to H3K56ac marked nascent DNA, revealing a role in replication fork restart and DNA damage repair.

Elucidating the combined toxicity of aflatoxin B1 and fumonisin B1 on HepG2 cells based on respirometry and transcriptome analyses

This study investigates the combined toxicity of aflatoxin B1 and fumonisin B1 on HepG2 cells using respirometry and transcriptome analyses, finding increased mitochondrial inhibition and p53 pathway disruption.

Transcriptional and translational dynamics underlying heat shock response in the thermophilic Crenarchaeon Sulfolobus acidocaldarius

This study investigates the heat shock response in Sulfolobus acidocaldarius using transcriptomic and proteomic analyses, revealing post-transcriptional and post-translational regulation mechanisms.

Single-cell profiling identifies a spectrum of human unconventional intraepithelial T lineage cells

The paper identifies a spectrum of human unconventional intraepithelial T lineage cells using single-cell RNA sequencing and defines their phenotypic and transcriptomic features.

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

This study shows that RUNX2 promotes human NK cell generation and tissue residency through IL-2Rβ induction, with implications for cancer therapy.

Standing covariation between genomic and epigenomic patterns as source for natural selection in wild strawberry plants

This study shows that SNPs and DMCs in wild strawberries covary under drought stress, suggesting genomic redundancy and polygenic adaptation.

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

This study shows that MYCN activation in RPE cells causes nucleolar stress and a senescence-like transcriptional program without full senescence hallmarks, leading to growth attenuation.

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.

This study shows that ADAR1's interaction with Z-RNA reduces A-to-I editing of self-dsRNA, leading to MDA5-dependent immune activation and AGS in mutant cells and mice.

RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

This study identifies RRM2 as a therapeutic target in high-risk neuroblastoma, showing that combined RRM2 and CHK1 inhibition synergistically reduces tumor growth.

Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions

This study shows that chromosomal imbalances in hESCs provide a proliferative advantage under replicative stress, similar to cancer cells.

Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

The paper shows that endogenous suppression of WNT signaling in hPSCs reduces differentiation efficiency towards definitive endoderm, and that increasing WNT or inhibiting PI3K/AKT can overcome this block.

Ecological divergence of DNA methylation patterns at distinct spatial scales

This study investigates how DNA methylation patterns diverge across spatial scales in Fragaria vesca plants, finding that epigenetic memories form at fine scales and are influenced by both parallel and non-parallel biological processes.

Various evolutionary trajectories lead to loss of the tobramycin-potentiating activity of the quorum sensing inhibitor baicalin hydrate in Burkholderia cenocepacia biofilms

This study shows that biofilms of Burkholderia cenocepacia develop resistance to the antibiotic-potentiating activity of baicalin hydrate through various genetic changes.

Positive human health effects of sea spray aerosols: molecular evidence from exposed lung cell lines.

The paper exposes lung cells to sea spray aerosols and finds positive molecular effects on the mTOR pathway and PCSK9 at environmentally relevant concentrations.