Targeting Spike Glycans to Inhibit SARS-CoV2 Viral Entry
A. J. Guseman, L. J. Rennick, S. Nambulli, C. N. Roy, D. Martinez, D. T. Yang, F. Bhinderwhala, S. Vergara, R. S. Baric, Z. Ambrose, W. P. Duprex, A. M. Gronenborn
This study shows that BOA, a lectin, binds to SARS-CoV-2 Spike glycans and inhibits viral entry at nanomolar concentrations, effective against variants of concern.
bioRxiv · Dec 22, 2022 · PreprintBiochemistry