Author

Z. Ambrose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:human· 3 Organism:non-human primate· 2 Assay:proteomics· 2 Assay:DNA methylation· 1 Approach:mechanistic / dynamical model· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. Engelman· 2 shared C. Kline· 2 shared J. Ahn· 2 shared S. C. Watkins· 2 shared A. D. Kashuba· 1 shared A. F. Feder· 1 shared A. G. White· 1 shared A. J. Guseman· 1 shared

Activity by Year

2017-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

A. Engelman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration

Z. Ingram, C. Kline, A. K. Hughson, P. K. Singh, H. L. Fischer, G. A. Sowd, S. C. Watkins, M. Kane, A. N. Engelman, Z. Ambrose

This study shows that sequential binding of CypA and CPSF6 to HIV-1 capsid is necessary for nuclear entry and integration, and that lenacapavir targets this process.

mBio · Apr 9, 2025Peer-reviewedMicrobiology

Targeting Spike Glycans to Inhibit SARS-CoV2 Viral Entry

A. J. Guseman, L. J. Rennick, S. Nambulli, C. N. Roy, D. Martinez, D. T. Yang, F. Bhinderwhala, S. Vergara, R. S. Baric, Z. Ambrose, W. P. Duprex, A. M. Gronenborn

This study shows that BOA, a lectin, binds to SARS-CoV-2 Spike glycans and inhibits viral entry at nanomolar concentrations, effective against variants of concern.

bioRxiv · Dec 22, 2022 · PreprintBiochemistry

Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent manner

Z. Zhong, J. Ning, E. A. Boggs, S. Jang, C. Wallace, C. Telmer, M. Bruchez, J. Ahn, A. Engelman, p. zhang, S. C. Watkins, Z. Ambrose

The paper shows CPSF6 and CypA interact to regulate HIV-1 capsid trafficking and infection by affecting capsid-CPSF6 complex formation and stability.

bioRxiv · Jun 5, 2020Microbiology

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

C. Xu, D. Fisher, S. Rankovic, W. Li, R. Dick, B. Runge, R. Zadorozhnyi, J. Ahn, C. Aiken, T. Polenova, A. Engelman, Z. Ambrose, I. Rousso, J. R. Perilla

This study investigates how HIV-1 capsid permeability to metabolites affects dNTP import and reverse transcription, revealing a mechanism involving IP6 and BHC.

bioRxiv · Apr 30, 2020Biophysics

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis

C. R. Diedrich, T. Rutledge, P. Maiello, T. M. Baranowski, A. G. White, H. J. Borish, P. Karell, F. Hopkins, J. Brown, S. M. Fortune, J. L. Flynn, Z. Ambrose, P. L. Lin

This study compares the effects of SIV infection and CD4 depletion on Mtb reactivation in a macaque model, finding that SIV promotes more severe granuloma dissemination and bacterial burden.

bioRxiv · Feb 21, 2020Immunology

High resolution spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host

A. F. Feder, C. Kline, P. Polacino, M. Cottrell, A. D. Kashuba, B. F. Keele, S.-L. Hu, D. A. Petrov, P. Pennings, Z. Ambrose

This study tracks SHIV evolution in macaques to show drug resistance spreads rapidly across compartments but does not equilibrate, with the gut showing faster turnover and less wild-type virus retention.

bioRxiv · Jan 4, 2017Evolutionary Biology