Author

S. Vergara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

G. Calero· 2 shared U. Santiago· 2 shared A. Chen· 1 shared A. J. Guseman· 1 shared A. M. Gronenborn· 1 shared B. Hu· 1 shared C. J. Camacho· 1 shared C. Jin· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

G. Calero

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structures of kinetic intermediate states of HIV-1 reverse transcriptase DNA synthesis

S. Vergara, X. Zhou, U. Santiago, J. F. Conway, N. Sluis-Cremer, G. Calero

This study captures 11 structures of HIV-1 reverse transcriptase during DNA synthesis, revealing intermediate states and mechanisms of dATP incorporation and drug resistance.

bioRxiv · Dec 18, 2023 · PreprintBiophysics

Targeting Spike Glycans to Inhibit SARS-CoV2 Viral Entry

A. J. Guseman, L. J. Rennick, S. Nambulli, C. N. Roy, D. Martinez, D. T. Yang, F. Bhinderwhala, S. Vergara, R. S. Baric, Z. Ambrose, W. P. Duprex, A. M. Gronenborn

This study shows that BOA, a lectin, binds to SARS-CoV-2 Spike glycans and inhibits viral entry at nanomolar concentrations, effective against variants of concern.

bioRxiv · Dec 22, 2022 · PreprintBiochemistry

A robust and versatile nanobody platform for drug delivery

Z. Shen, Y. Xiang, S. Vergara, A. Chen, Z. Xiao, U. Santiago, C. Jin, Z. Sang, J. Luo, K. Chen, D. Schneidman-Duhovny, C. J. Camacho, G. Calero, B. Hu, Y. Shi

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

bioRxiv · Aug 19, 2020 · PreprintBioengineering