Author

W. P. Duprex

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 7 Organism:human· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:non-human primate· 2

Frequent Co-Authors

S. Nambulli· 8 shared L. J. Rennick· 6 shared A. K. McElroy· 2 shared A. L. Hartman· 2 shared C. M. McMillen· 2 shared D. S. Reed· 2 shared K. R. McCarthy· 2 shared L. R. Robinson-McCarthy· 2 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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8 shared papersMicrobiology

S. Nambulli

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Targeting Spike Glycans to Inhibit SARS-CoV2 Viral Entry

A. J. Guseman, L. J. Rennick, S. Nambulli, C. N. Roy, D. Martinez, D. T. Yang, F. Bhinderwhala, S. Vergara, R. S. Baric, Z. Ambrose, W. P. Duprex, A. M. Gronenborn

This study shows that BOA, a lectin, binds to SARS-CoV-2 Spike glycans and inhibits viral entry at nanomolar concentrations, effective against variants of concern.

bioRxiv · Dec 22, 2022 · PreprintBiochemistry

Sustained replication of synthetic canine distemper virus defective genomes in vitro and in vivo

N. Tilston-Lunel, S. R. Welch, S. Nambulli, R. D. de Vries, G. Ho, D. Wentworth, R. S. Shabman, S. T. Nichol, C. F. Spiropoulou, R. L. de Swart, L. J. Rennick, W. P. Duprex

This paper generates and characterizes defective interfering genomes of canine distemper virus, showing their sustained replication in vivo and potential as therapeutic agents.

mSphere · Oct 27, 2021Peer-reviewedMicrobiology

Molecular assembly of measles and Nipah virus: specific lipid binding drives conformational change and matrix polymerization

M. J. Norris, M. L. Husby, W. B. Kiosses, J. Yin, L. J. Rennick, A. Heiner, S. S. Harkins, R. Pokhrel, S. L. Schendel, K. M. Hastie, S. Landeras-Bueno, Z. Li Salie, B. Lee, P. P. Chapagain, A. Maisner, , E. Ollmann Saphire

This study identifies how measles and Nipah virus M proteins bind specific lipids, inducing conformational changes that drive virion assembly.

bioRxiv · Oct 11, 2021 · PreprintMicrobiology

Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

P. Tong, A. Gautam, I. Windsor, M. Travers, Y. Chen, N. Garcia, N. Whiteman, L. McKay, F. J. N. Lelis, S. Habibi, Y. Cai, L. J. Rennick, W. P. Duprex, K. McCarthy, C. L. Lavine, , D. R. Wesemann

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

bioRxiv · Mar 10, 2021Immunology

Deletion disrupts a conserved antibody epitope in a SARS-CoV-2 variant of concern

L. L. Rennick, L. R. Robinson-McCarthy, S. Nambulli, W. P. Duprex, K. R. McCarthy

The paper identifies a SARS-CoV-2 variant with a deletion in the RBD that disrupts a conserved antibody epitope across sarbecoviruses.

bioRxiv · Mar 5, 2021 · PreprintMicrobiology

Bifurcated monocyte states are predictive of mortality in severe COVID-19

A. R. Cillo, A. Somasundaram, F. Shan, C. Cardello, C. J. Workman, G. D. Kitsios, A. Ruffin, S. Kunning, C. Lampenfeld, S. Onkar, S. Grebinowski, G. Deshmukh, B. Methe, C. Liu, S. Nambulli, , D. A. Vignali

The paper identifies bifurcated monocyte states in severe COVID-19 patients that predict mortality, with distinct cytokine and interferon gene modules associated with survival or death.

bioRxiv · Feb 10, 2021 · PreprintImmunology

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

K. R. McCarthy, L. J. Rennick, S. Nambulli, L. R. Robinson-McCarthy, W. G. Bain, G. Haidar, W. P. Duprex

The paper identifies recurrent deletions in the SARS-CoV-2 spike glycoprotein that drive antibody escape by altering epitopes and accelerating antigenic evolution.

bioRxiv · Nov 19, 2020Microbiology

Measles skin rash: infection of lymphoid and myeloid cells in the dermis precedes viral dissemination to keratinocytes in the epidermis

B. M. Laksono, P. Fortugno, B. M. Nijmeijer, R. D. de Vries, S. Cordisco, S. van Nieuwkoop, T. Kuiken, T. B. H. Geijtenbeek, W. P. Duprex, F. Brancati, R. L. de Swart

This study investigates measles skin rash pathogenesis, showing that viral infection of dermal lymphoid and myeloid cells precedes dissemination to epidermal keratinocytes, with nectin-4 dependency for keratinocyte infection.

PLOS Pathogens · Oct 8, 2020Peer-reviewedMicrobiology

Versatile, Multivalent Nanobody Cocktails Efficiently Neutralize SARS-CoV-2

Y. Xiang, S. Nambulli, Z. Xiao, H. Liu, Z. Sang, W. P. Duprex, D. Schneidman-Duhovny, C. Zhang, Y. Shi

This paper identifies potent SARS-CoV-2 neutralizing nanobodies, develops multivalent cocktails with high neutralization potency, and highlights their therapeutic potential.

bioRxiv · Aug 24, 2020Bioengineering

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tracts

A. L. Hartman, S. Nambulli, C. M. McMillen, A. G. White, N. Tilston-Lunel, J. R. Albe, E. L. Cottle, M. D. Dunn, L. J. Frye, T. H. Gilliland, E. L. Olsen, K. J. O'Malley, M. M. Schwarz, J. A. Tomko, R. C. Walker, , W. P. Duprex

bioRxiv · Jun 20, 2020Microbiology

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients

W. B. Klimstra, N. L. Tilston-Lunel, S. Nambulli, J. Boslett, C. M. McMillen, T. Gilliland, M. D. Dunn, C. Sun, S. E. Wheeler, A. Wells, A. L. Hartman, A. K. McElroy, D. S. Reed, L. J. Rennick, W. P. Duprex

The paper investigates SARS-CoV-2 growth, furin-cleavage-site adaptation, and neutralization using serum from hospitalized COVID-19 patients, finding neutralizing antibody titers are comparable regardless of furin cleavage signal integrity.

bioRxiv · Jun 19, 2020Microbiology