Author

C. P. Broedersz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Harju· 3 shared J. O. Raedler· 3 shared A. Fink· 2 shared D. B. Brueckner· 2 shared S. Zahler· 2 shared A. Joetten· 1 shared A. M. Vollmar· 1 shared A. Roidl· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiophysics

J. Harju

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Ion-mediated condensation controls the mechanics of mitotic chromosomes

H. Witt, J. Harju, E. M. Chameau, C. M. Bruinsma, T. V. Clement, C. F. Nielsen, I. D. Hickson, E. J. Peterman, C. P. Broedersz, G. J. Wuite

The paper shows that ion-mediated condensation controls the mechanical properties of mitotic chromosomes through polymer-like behavior and chromatin loop interactions.

Nature Materials · Sep 16, 2024Peer-reviewedBiophysics

Unravelling the metastasis-preventing effect of miR-200c in vitro and in vivo

B. Koehler, E. Brieger, T. Brandstaetter, E. Hoerterer, U. Wilk, J. Poehmerer, A. Joetten, P. Paulitschke, C. P. Broedersz, S. Zahler, J. O. Raedler, E. Wagner, A. Roidl

This study shows that miR-200c expression reduces metastasis in vivo and inhibits cell migration in vitro in breast cancer models.

bioRxiv · Nov 14, 2023 · PreprintCancer Biology

Loop-extruders alter bacterial chromosome topology to direct entropic forces for segregation

J. Harju, M. C. F. van Teeseling, C. P. Broedersz

The paper develops a biophysical model showing loop-extruders enhance entropic forces for bacterial chromosome segregation during replication.

bioRxiv · Jun 30, 2023 · PreprintBiophysics

Physical models for chromosome organization to predict multi-contact statistics

J. Harju, J. J. B. Messelink, C. P. Broedersz

The paper develops three predictors of multi-contact frequencies using physical models and applies them to experimental data, finding that loop-extrusion explains observed three-point contacts.

bioRxiv · May 17, 2022 · PreprintBiophysics

Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration

T. Zisis, D. B. Brückner, T. Brandstätter, J. d'Alessandro, A. M. Vollmar, C. P. Broedersz, S. Zahler

This study investigates how cadherin-mediated cell-cell interactions influence collective cancer cell migration by combining theoretical modeling and in vitro experiments.

bioRxiv · May 7, 2021Biophysics

Area and Geometry Dependence of Cell Migration in Asymmetric Two-State Micropatterns

A. Fink, D. B. Brueckner, C. Schreiber, P. J. F. Roettgermann, C. P. Broedersz, J. O. Raedler

This study investigates how cell migration in asymmetric two-state micropatterns depends on area, shape, and orientation of adhesion sites, revealing occupancy probability ratios and transition rate dependencies.

bioRxiv · Oct 22, 2019Biophysics

Disentangling the Behavioural Variability of Confined Cell Migration

D. B. Brueckner, A. Fink, J. O. Raedler, C. P. Broedersz

The paper quantifies cell migration variability in human breast cancer cells using a dynamical systems approach, revealing additional variance due to aging and population heterogeneity.

bioRxiv · Oct 8, 2019Biophysics