Author

H. Witt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Janshoff· 2 shared J. Forsting· 2 shared J. Kraxner· 2 shared S. Koester· 2 shared A. Gallemi-Perez· 1 shared A. Guenther· 1 shared A. M. Cordes· 1 shared A. V. Schepers· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

A. Janshoff

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Ion-mediated condensation controls the mechanics of mitotic chromosomes

H. Witt, J. Harju, E. M. Chameau, C. M. Bruinsma, T. V. Clement, C. F. Nielsen, I. D. Hickson, E. J. Peterman, C. P. Broedersz, G. J. Wuite

The paper shows that ion-mediated condensation controls the mechanical properties of mitotic chromosomes through polymer-like behavior and chromatin loop interactions.

Nature Materials · Sep 16, 2024Peer-reviewedBiophysics

Pre-stress of actin cortices is important for the viscoelastic response of living cells

A. M. Cordes, H. Witt, A. Gallemi-Perez, B. R. Brueckner, F. Grimm, M. Vache, T. Oswald, D. Floormann, F. Lautenschlaeger, M. Tarantola, A. Janshoff

This study investigates how pre-stress in actin cortices affects the viscoelastic properties of living cells using a novel model and atomic force microscopy.

bioRxiv · Mar 25, 2020 · PreprintBiophysics

Context-dependent role of vinculin in neutrophil adhesion, motility and trafficking

Z. S. Wilson, H. Witt, L. Hazlett, M. Harman, B. M. Neumann, A. Whitman, M. Patel, R. S. Ross, C. Franck, J. S. Reichner, C. T. Lefort

This study investigates the role of vinculin in neutrophil adhesion, motility, and trafficking, finding that it partially affects adhesion and spreading but is dispensable for recruitment in vivo.

bioRxiv · Nov 20, 2019Immunology

Vimentin intermediate filaments undergo irreversible conformational changes during cyclic loading

J. Forsting, J. Kraxner, H. Witt, A. Janshoff, S. Koester

This study shows vimentin intermediate filaments undergo irreversible conformational changes under cyclic loading, introducing a third state to explain their mechanical behavior.

bioRxiv · Sep 25, 2019Biophysics

Lateral Subunit Coupling Determines Intermediate Filament Mechanics

C. Lorenz, J. Forsting, A. V. Schepers, J. Kraxner, S. Bauch, H. Witt, S. Klumpp, S. Koester

This study compares the mechanical properties of keratin and vimentin filaments, showing vimentin's mechanics depend on ionic strength and involve strong lateral subunit coupling.

bioRxiv · Jun 19, 2019Biophysics

Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition

R. M. Wasnick, M. Korfei, K. Piskulak, I. Henneke, J. Wilhelm, P. Mahavadi, D. von der Beck, M. Koch, I. Shalashova, O. Klymenko, L. Fink, H. Witt, H. Hackstein, E. El Agha, S. Bellusci, , A. Guenther

Notch1 inhibition restores alveolar epithelial differentiation, reduces surface tension, and reverses matrix deposition in lung fibrosis.

bioRxiv · Mar 23, 2019 · PreprintCell Biology