Self-organization of kinetochore-fibers in human mitotic spindles
W. Conway, R. Kiewisz, G. Fabig, C. P. Kelleher, H.-Y. Wu, M. Anjur-Dietrich, T. Mueller-Reichert, D. Needleman
This study investigates how kinetochore microtubules (KMTs) organize in human mitotic spindles using electron tomography, experiments, and modeling, finding that KMTs grow along defined trajectories and predominantly nucleate de novo at kinetochores.
bioRxiv · Nov 11, 2021Biophysics