H.-Y. Wu

Clustering of cortical dynein regulates the mechanics of spindle orientation in human mitotic cells

This study measures forces on human mitotic spindles and shows that cortical dynein clustering determines spindle orientation mechanics.

Isolation and whole genome characterization of antagonistic Paenibacillus polymyxa 188 and its biocontrol potential against several fungi

This study isolates and characterizes Paenibacillus polymyxa 188, identifying its antifungal compounds and genome, showing its potential as a biocontrol agent.

Laser Ablation and Fluid Flows Show a Single Force Mechanism Governs Spindle Positioning

The paper develops two techniques to study subcellular forces and applies them to show cortical pulling forces govern centrosome-related behaviors in C. elegans embryos.

Self-organization of kinetochore-fibers in human mitotic spindles

This study investigates how kinetochore microtubules (KMTs) organize in human mitotic spindles using electron tomography, experiments, and modeling, finding that KMTs grow along defined trajectories and predominantly nucleate de novo at kinetochores.

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

Selective protein O-GlcNAcylation in cells by a proximity-directed O-GlcNAc transferase

This paper introduces a method to selectively induce O-GlcNAcylation on target proteins using nanobody-fused OGT, enabling precise study of O-GlcNAc modifications in cells.

Discovery of a celecoxib binding site on PTGES with a cleavable chelation-assisted biotin probe

This paper identifies a new celecoxib binding site on PTGES using a cleavable chelation-assisted biotin probe and validates it through competitive displacement and structural modeling.

Central spindle microtubules are strongly coupled to chromosomes during both anaphase A and anaphase B

The paper measures central spindle microtubule movement during chromosome segregation in human and C. elegans spindles, finding they slide apart at the same speed as chromosomes and are strongly coupled to them.