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5 papers
Recent·Most cited
W. Conway, L. Qiu, G. Ha, A. Amir, D. J. Needleman
This paper investigates how kinetochore microtubules detach by combining experimental measurements and modeling, revealing a dual mechanism involving NDC80 complex binding energetics and microtubule catastrophe.
bioRxiv · Jun 5, 2023 · PreprintBiophysics
R. Kiewisz, G. Fabig, W. Conway, D. Baum, D. Needleman, T. Muller-Reichert
This paper uses electron tomography to reveal the 3D structure of kinetochore-fibers in human mitotic spindles, showing nine KMTs per fiber and structural variations along their length.
bioRxiv · Nov 13, 2021Cell Biology
W. Conway, R. Kiewisz, G. Fabig, C. P. Kelleher, H.-Y. Wu, M. Anjur-Dietrich, T. Mueller-Reichert, D. Needleman
This study investigates how kinetochore microtubules (KMTs) organize in human mitotic spindles using electron tomography, experiments, and modeling, finding that KMTs grow along defined trajectories and predominantly nucleate de novo at kinetochores.
bioRxiv · Nov 11, 2021Biophysics
M. Venturas, J. S. Shah, X. Yang, T. H. Sanchez, W. Conway, D. Sakkas, D. J. Needleman
This study uses FLIM to measure metabolic state in human blastocysts, finding metabolic differences related to time since fertilization and developmental stage, but not morphology.
bioRxiv · Jul 9, 2021Cell Biology
T. Y. Yoo, J.-M. Choi, W. Conway, C.-H. Yu, R. V. Pappu, D. J. Needleman
The paper measures NDC80 binding to microtubules in living cells and finds it is regulated by centromere tension and phosphorylation of Hec1.
bioRxiv · Jun 27, 2018Cell Biology